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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
MetabolomicsTranscriptional memory of dFOXO activation in youth curtails later-life mortality
Identifying processes occurring in early life affect subsequent life and health span is an urgent aim to improve human health. In this study, we identified a novel mechanism of dFOXO in longevity determination in Drosophila. We found that early adulthood induction of dFOXO is sufficient to reduce mo...
2022-09-28 | MTBLS3251 | MetaboLights
TranscriptomicsExpression data from pig uterus in response to embryos at blastocyst satge and oocytes
The maternal tract plays a critical role in the success of early embryonic development providing an optimal environment for establishment and maintenance of pregnancy. Preparation of this environment requires an intimate dialogue between the embryo and her mother. To advance our understanding of the...
ORGANISM(S): Sus scrofa 
2012-04-18 | E-GEOD-33262 | biostudies-arrayexpress
TranscriptomicsMolecular response of Atinian elm during vessel invasion by vascular pathogen Ophiostoma novo-ulmi
6-year-old ramets of U. minor (Atinian elm clone) were inoculated with O. novo-ulmi in order to evaluate molecular responses activated during plant colonization. To elucidate the different genes involved in the U. minor immune system and the molecular changes suffered after inoculation, oligomicroar...
ORGANISM(S): Ulmus minor 
2017-12-31 | E-MTAB-5654 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell lines treated with cytochalasin D and nocodazole with the aim of characterising tetraploid clones
During the oncogenic process, tetraploidy is a candidate intermediate stage leading from diploidy to aneuploidy. The aim of our experiment was to establish tetraploid clones and to characterize their transcriptome.
ORGANISM(S): Homo sapiens 
2006-03-01 | E-TABM-70 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cell lines produced from premalignant tumors with induced sensence
Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2487 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells, or whole blood were isolated 0, 30 min, 6 h, 24 h, and 7 day after intravenous endotoxin challenge vs controls
Peripheral blood mononuclear cells were isolated 0, 30 min, 6 h, 24 h, and 7 day after intravenous endotoxin challenge using cell preparation tubes (Vacutainer® CPT). The PBMC layer was lysed with RLT buffer, homogenized, and then stored at –80°C. Total RNA was extracted as per RNeasy‚ Midi protocol...
ORGANISM(S): Homo sapiens 
2007-12-19 | E-GEOD-3026 | biostudies-arrayexpress
UnknownFecal immunochemical test accuracy in average-risk colorectal cancer screening.
Not available
S-EPMC3921527 | biostudies-literature
UnknownFingerprints as Predictors of Schizophrenia: A Deep Learning Study.
Not available
S-EPMC10154725 | biostudies-literature
TranscriptomicsExpression data from skin fibroblasts derived from Setleis Syndrome patients and normal controls
Setleis Syndrome is a rare type of facial ectodermal dysplasia characterized by an aged leonine appearance with puckered skin about the eyes, absent eyelashes on both lids or multiple rows on the upper lids and none on the lower lids, eyebrows that slant sharply upward laterally, and a rubbery feel ...
ORGANISM(S): Homo sapiens 
2009-06-11 | E-GEOD-16524 | biostudies-arrayexpress
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