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ProteomicsDifferent protein cargo of extracellular vesicles from yeast or hyphal Candida albicans cells
Extracellular vesicles (EVs) are shed from cells of almost every type of cell or organism. These nano- to micrometer scaled lipid bilayer delimited spheres shuttle a set of bioactive molecules involved in many processes including cell-cell communication, host-pathogen interactions and even the shari...
ORGANISM(S): Candida albicans (Yeast) 
2022-04-07 | PXD021488 | Pride
Hyphae Dimorphic transition C. albicans Extracelullar vesicles Yeast Proteome 
ProteomicsHuman THP1 macrophages after interacting with C. albicans, using ATP-binding protein enrichment strategy
Macrophages are involved in the primary human host response to pathogens such as Candida albicans. After pathogen recognition by specific receptors, a cascade of signaling pathways is activated, leading to the production of cytokines, chemokines and antimicrobial peptides. ATP binding proteins are c...
ORGANISM(S): Candida albicans (Yeast) 
2019-04-18 | PXD009938 | Pride
Phosphopeptides Silac Atp-binding proteins Macrophages Candida albicans 
ProteomicsLabel free comparison of the protein cargo of extracellular vesicles (EVs) isolated from SC5314 and ecm33∆ mutant cells of Candida albicans after 16 hours of growth in YPD medium
Given the tendency to substitute cellular vaccines with acellular ones, and the complete lack of virulence shown by the C. albicans cell wall mutant ecm33∆, we performed the characterization of its EVs and test their possible use as vaccine for invasive candidiasis. Label free proteomics was carried...
ORGANISM(S): Candida albicans (Yeast) 
2025-05-07 | PXD055891 | Pride
C. albicans Ecm33 mutant Extracellular vesicles 
ProteomicsProteomic analysis for the study of Prn1 function, a protein similar to pirins. Identification and quantification of proteins whose expression changes in absence of Prn1 after hydrogen peroxide exposure.
In C. albicans, after yeast-macrophage interaction up to 30% of yeast cells suffers oxidative stress mediated-apoptosis. In previous studies to reveal the response mechanisms to oxidative stress of this yeast we performed a quantitative proteomic analysis in cells exposed to hydrogen peroxide to eva...
ORGANISM(S): Candida albicans (Yeast) 
2024-06-16 | PXD040804 | Pride
Oxidative stress. Quantitative proteomics C. albicans Prn1 Pirins 
ProteomicsCreation of a Candida albicans spectral library by Data Dependent Acquisition (DDA)
The incidence of candidiasis, caused mainly by the opportunistic fungal Candida albicans, remains a major concern in public health due to the emerging antifungal resistance. C. albicans modulates their proteome under different conditions trying to cope with several stressors in host niches. In this ...
ORGANISM(S): Candida albicans (Yeast) 
2021-09-30 | PXD020195 | Pride
Candida albicans Macrophages Dda ms Dia ms Hydrogen peroxide Acetic acid Spectral library 
ProteomicsEvaluating the stress response in Candida albicans by data independent acquisition (DIA) proteomics
Candida albicans is a fungal opportunistic pathogen responsible for cause severe infections in immunocompromised patients. Despite nowadays an effective antifungal armoury is available, the emergence of antifungal resistance is promoting the urge to develop alternative treatments to combat this fung...
ORGANISM(S): Candida albicans (Yeast) 
2021-09-13 | PXD020283 | Pride
Candida albicans Dia ms Oxidative stress Apoptosis Acetic acid Proteasome 
ProteomicsCandida albicans phosphoproteome analysis after exposure to hydrogen peroxide
Invasive candidiasis is among the fungal infections that cause more deaths in the world in immunocompromised patients. The main species responsible for these infections is Candida albicans, an opportunistic pathogen found in the microbiota of healthy individuals; however, states of immunosuppression...
ORGANISM(S): Candida albicans SC5314 
2025-06-24 | PXD035231 | Pride
Candida albicans Shotgun Phosphoproteome Oxidative stress Hydrogen peroxide 
ProteomicsDifferent protein cargo of whole cell lysates from yeast or hyphal Candida albicans cells
Whole cell lysates from yeast or hyphal Candida albicans cells were obtained and proteins were analysed by MS in order to have a global view of proteome differences between both fungal morphologies. This analysis constitute an interesting approach to decipher proteomic differences underlying morphol...
ORGANISM(S): Candida albicans (Yeast) 
2021-09-13 | PXD021504 | Pride
Hyphae Cytoplasmic extract Dimorphic transition C. albicans Yeast Proteome 
ProteomicsIron and Copper induce proteomic changes related to the expression of virulence factors in clinical isolates of Cryptococcus neoformans
Minerals are essential for proper cell function. In infectious processes where both cells of the causative agent and the host itself are involved, competition for their acquisition is necessary. In this context, pathogenic fungi have developed machinery to ensure the acquisition of minerals and at t...
ORGANISM(S): Cryptococcus neoformans var. grubii VNI 
2022-02-16 | PXD021687 | Pride
Protein Cryptococcus neoformans Minerals Clinical Iron Copper Cryptocosis 
ProteomicsProteome of candida glabrata after Caspofungin exposure
Caspofungin resistance is a great concern, as the echinocandin drugs are recommended as first-line therapy for invasive candidiasis. Echinocandin resistance is conferred by mutations in FKS genes. Nevertheless, some pathways which regulate cellular stress responses could be crucial for enabling the ...
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2022-04-04 | PXD021578 | Pride
Lc ms/ms Candida glabrata Caspofungin Preteome 
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