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ProteomicsA Tale of Two Follicles: Proteomic Clues to Oocyte Success and Failure
Women are born with thousands of follicles in their ovaries but less than 1% will produce a mature oocyte. What distinguishes the 99% of ovarian follicles destined for demise from the rare 1% that succeed? Here, we leveraged a unique clinical opportunity, paired follicular fluid samples from small a...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD063187 | Pride
Metabolism Atresia Fertility preservation Oocyte maturation Follicular fluid 
ProteomicsAI-based digital pathology and spatial proteomics enable precision oncology: A case report of recurrent melanoma in a young patient
Background: Metastatic melanoma presents clinical challenges due to tumor heterogeneity and resistance mechanisms, especially when standard treatments fail. Recent advances in artificial intelligence (AI) and spatial proteomics have opened new avenues for precision oncology. Exploring these principl...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD073928 | Pride
Precision oncology Ai-digital pathology Laser capture microdissection Melanoma Spatial proteomics 
ProteomicsHigh-Throughput Acoustic FFPE Proteomics Reveals ATP5IF1-Associated Mitochondrial Remodeling in Acral Melanoma
Formalin-fixed, paraffin-embedded (FFPE) archives underpin dermatopathology and translational oncology, enabling clinically annotated melanoma cohorts, but cohort-scale proteomics remains limited by labor and variability in upstream processing. We established a plate-scale, acoustic FFPE proteomics ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD074156 | Pride
Ai-digital pathology  atp synthase inhibitor if1  adaptive focused acoustics  acral melanoma Oxidative phosphorylation  plate-scale ffpe proteomics 
ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo sapiens (Human) 
2017-09-12 | PXD005903 | Pride
Deacetylase inhibitor Sirt1 Cancer cells Lysine acetylation Stoichiometry Proteomics 
ProteomicsQuantitative proteomics reveals proteins involved in the progression from non-cancerous lesions to gastric cancer
Gastric cancer (GC) is among the most aggressive malignancy affecting the world population. With almost a million cases remains in fifth position in incidence, while reaching the third position in mortality. The progression of GC is slow with several prolonged and sequential precancerous stages, inc...
ORGANISM(S): Homo sapiens (Human) 
2019-09-27 | PXD008081 | Pride
Quantitative proteomics Cancer progression Chronic gastritis Intestinal metaplasia Gastric cancer Itraq labelling 
ProteomicsDistinct sub-cellular autophagy impairments occur independently of protein aggregation in aged induced neurons from patients with Huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder that is caused by CAG expansions in the huntingtin (HTT) gene. Modelling HD in the lab has proven challenging as rodent models poorly reproduce the disease process and cellular models fail to include age-dependent processes crucial...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD024286 | Pride
Autophagy Direct neural reprogramming Huntington disease Crispr interference Proteogenomics Lentiviral vector 
ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-09 | MSV000081704 | MassIVE
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