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TranscriptomicsETV5 transcription program links BDNF and promotion of EMT at invasive front of endometrial carcinomas.
We have characterized the transcriptional program regulated by ETV5 at the invasive front of endometrial carcinomas, by comparing it with non-invasive areas of the same tumor samples. In total 12 samples; 6 superficial (non-invasive) tumor areas and the corresponding invasive tumor zones.
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-57870 | biostudies-arrayexpress
MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
TranscriptomicsParedes_IPATIMUP_Comparison of cell lines derived from BT-20 cells using siRNA to silence E-cadherin and P-cadherin
Gene expression of four cell lines derived from BT-20 cells, namely, BT20 siCtr (E+/P+), BT20 siPcad (E+/P-), BT20 siEcad (E-/P+), and BT20 siEPcad (E-/P-) was compared using Agilent Human GE 4x44k v2 Microarrays and the Agilent One-Color Microarray-Based Gene Expression Analysis protocol (Quick Amp...
ORGANISM(S): Homo sapiens 
2011-10-01 | E-MEXP-3329 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat intact CNS tissue in vitro using rat organotypic hippocampal slice cultures after anti-Nogo-A antibody treatment
The neurite outgrowth inhibitory myelin protein Nogo-A has been well studied in the context of central nervous system (CNS) injury and disease. We studied the effects of the application of neutralizing anti-Nogo-A antibodies (11C7 and 7B12) in intact CNS tissue in vitro using rat organotypic hippoca...
ORGANISM(S): Rattus norvegicus 
2008-11-15 | E-GEOD-12483 | biostudies-arrayexpress
TranscriptomicsRNA-seq of wild-type Salmonella Typhimurium SL1344 in the presence and absence of chlorpromazine or Phe-Arg-Beta-Napthylamide
The aim of this experiment was to determine the changes in transcription caused by inhibition of efflux pumps by the Phe-Arg-Beta-Naptylamide (PABN) and chlorpromazine. Four biological replicates per condition were grown to mid-log phase in MOPS minimal media (OD600) and were exposed to the known ef...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2020-06-01 | E-MTAB-8190 | biostudies-arrayexpress
UnknownRestricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response
Not available
S-SCDT-10_1038-S44321-025-00250-2 | biostudies-other
TranscriptomicsRegulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a g...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-16187 | biostudies-arrayexpress
TranscriptomicsCDK inhibitor PHA-848125 gene expression profiling on MCF7 cell line
The effects of the CDK inhibitor PHA-848125 (referred to as CDK-125) on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. The MCF7 cell line was treated with PHA-848125 for 6 hours at a dose equal to 5 times the IC50. Untreated MCF7 cells were used as a con...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of adult drosophila renal tubule vs whole fly
The experiment was designed to identify genes abundant or enriched in adult Drosophila melanogaster Malpighian (renal) tubule as compared to the whole fly.
ORGANISM(S): Drosophila melanogaster 
2004-06-23 | E-MEXP-127 | biostudies-arrayexpress
Proteomics,MultiomicsRaj_nSR100_interactions_P36_V21_P105_V17
This submission includes the mass spectrometry data for the manuscript by Raj et al. (nSR100 regulation of an exon network required for neurogenesis). This submission contains files for Srrm4 (aka nSR100) interactions from mouse N2A cells acquired on a 5600 TripleTOF mass spectrometer and files for...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2014-04-23 | MSV000078609 | MassIVE
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