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TranscriptomicsConserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response
Discriminating pathogenic bacteria from energy-harvesting commensals is key to host immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the Caenorhabidits elegans innate immune response. Using w...
ORGANISM(S): Caenorhabditis elegans 
2015-05-01 | E-GEOD-53732 | biostudies-arrayexpress
ProteomicsThe OGT TPR Interactome defined by BioID
BioID performed in HeLa cells for the TPR domain of The O-GlcNAc Transferase and eGFP (negative control). Used to determine TPR interactors and the TPR interactome in HeLa cells. Three biological replicates were performed, with each replicate having an experimental (TPR-BirA*) and negative (eGFP-Bir...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-24 | MSV000085626 | MassIVE
ProteomicsProteomic identification of the UDP-GlcNAc : PI α1-6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei.
The first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis in all eukaryotes is the addition of N-acetylglucosamine (GlcNAc) to phosphatidylinositol (PI) which is catalysed by a UDP-GlcNAc : PI α1-6 GlcNAc-transferase. This enzyme has been shown to be a complex of at least seven subuni...
ORGANISM(S): Trypanosoma brucei 
2021-02-26 | PXD022979 | Pride
Glcnac-transferase Tbarv1 Trypanosoma brucei Glycosylphosphatidylinositol 
TranscriptomicsCharacterization of a novel mutation in O-GlcNAc transferase that segregates with disease in a family with X-linked intellectual disability
An X-chromosome exome sequencing analysis identified a mutation in O-GlcNAc transferase (OGT) (pL254F) in a family with X-linked intellectual disability (XLID). Affected patient lymohoblastoids exhibit decreased steady state OGT levels owing to an unstable protein compared to the unaffected, related...
ORGANISM(S): Homo sapiens 
2016-02-25 | E-GEOD-74263 | biostudies-arrayexpress
ProteomicsZscan4 as a candidate conveyor of early developmental defects in O-GlcNAc transferase intellectual disability
Variants in the human β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) gene give rise to an intellectual disability (ID) syndrome termed OGT congenital disorder of glycosylation (OGT-CDG). The mechanisms by which loss of OGT and/or protein O-GlcNAcylation lead to this syndrome are not understood, ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-03 | PXD064425 | Pride
O-glcnac transferase Tmt Mouse 
GenomicsO-GlcNAc Transferase Promotes Eomesodermin-mediated Exhaustion of CD8+ Cytotoxic T Lymphocytes
O-GlcNAc Transferase Promotes Eomesodermin-mediated Exhaustion of CD8+ Cytotoxic T Lymphocytes
PRJNA1271106 | ENA
GenomicsSingle cell RNA sequencing on chronic deletion of hepatic O-GlcNAc Transferase in mice
Single cell RNA sequencing on chronic deletion of hepatic O-GlcNAc Transferase in mice
PRJNA928477 | ENA
ProteomicsMammalian Cell Proliferation Requires Noncatalytic Functions of O-GlcNAc Transferase
O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell types, is essential for cell proliferation. Why OGT is required for cell growth is not known. OGT performs two enzymatic reactions in the same active site. In one, it glycosylates thousands of different proteins, an...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022654 | Pride
O-glcnac transferase Ogt Enzyme Cell proliferation Hcf-1 
TranscriptomicsDrosophila Oga deletion perturbs O-GlcNAcylation of chromatin factors
Drosophila development is a complex and dynamic process regulated, in part, by members of the Polycomb (Pc), Trithorax (Trx) and Compass chromatin modifier complexes. O-GlcNAc Transferase (OGT/SXC) is essential for Pc repression suggesting that the O-GlcNAcylation of proteins plays a key role in re...
ORGANISM(S): Drosophila melanogaster 
2016-07-21 | E-GEOD-74846 | biostudies-arrayexpress
TranscriptomicsExpression data from HEK293 cells with or without MIBP1 overexpression
The transcription factor c-MYC intron binding protein 1 (MIBP1) binds to various genomic regulatory regions, including intron 1 of c-MYC. This factor is highly expressed in post-mitotic neurons in the fetal brain and may be involved in various biological steps, such as neurological and immunological...
ORGANISM(S): Homo sapiens 
2012-01-31 | E-GEOD-26420 | biostudies-arrayexpress
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