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ProteomicsHigh-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Glioblastoma, the most aggressive primary brain cancer, has dismal prognosis, yet systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies may emerge from exploring neurodevelopmental and neurophysiological vulnerabilities of glioblastoma. To this end, we here syste...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090357 | MassIVE
TranscriptomicsTranscriptomal Diversity of Long-Term Glioblastoma Survivors
Glioblastoma (GBM) is a highly aggressive type of glioma with poor prognosis. However, a small number of patients live much longer than the median survival. A better understanding of these long-term survivors (LTS) may provide important insight into the biology of GBM. We identified 7 patients with ...
ORGANISM(S): Homo sapiens 
2014-05-02 | E-GEOD-54077 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human glioblastoma pseudopalisading cells
By comparing to common tumor cells, genes were differencially expressed in pseudopalisading cells in human glioblastoma
ORGANISM(S): Homo sapiens 
2007-08-21 | E-GEOD-2485 | biostudies-arrayexpress
TranscriptomicsPatient specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ (CGH)
Frequent discrepancies between preclinical and clinical results of anti-cancer agents demand a reliable translational platform that can precisely recapitulate the biology of human cancers. Another critical unmet need is the ability to predict therapeutic responses for individual patients. Toward thi...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-42577 | biostudies-arrayexpress
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084343 | MassIVE
TranscriptomicsExpression data from primary Glioblastoma in adults
Gene expression profiling revealed over-representation of a distinct (proneural-like) expression signature in long-term survivors that was linked to IDH1/2 mutation. However, among the IDH1/2-wildtype patients, tumors from long-term survivors did not show distinct gene expression profiles and includ...
ORGANISM(S): Homo sapiens 
2014-03-27 | E-GEOD-53733 | biostudies-arrayexpress
TranscriptomicsPatient specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ (gene expression)
Frequent discrepancies between preclinical and clinical results of anti-cancer agents demand a reliable translational platform that can precisely recapitulate the biology of human cancers. Another critical unmet need is the ability to predict therapeutic responses for individual patients. Toward thi...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-42669 | biostudies-arrayexpress
ProteomicsSerum N-glycomics with nanoLC-QToF LC-MS/MS reveals N-glycan biomarkers for glioblastoma, meningioma, and high-grade meningioma
Alteration of glycosylation in cancer cells leaded to the expression of tumor-associated glycans that could be used as a biomarker for diagnosis and prognostic prediction of the diseases. In this study, we used nanoLC-QToF LC-MS/MS for the identification of serum N-glycan biomarkers for detection of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-03 | MSV000096282 | MassIVE
TranscriptomicsProfiling by array of human Glioblastoma multiforme (GBM) tumor samples to asses the intra-tumoral heterogeneity in genomic copy number aberrations
Glioblastoma multiforme (GBM) is a highly heterogeneous disease that shows an wide range of genetic abnormalities in comparison to other astrocytic tumors. We have extracted between 4 and 8 tumor subsamples from different areas of the malignant tissue that were at least 1cm apart. Our aim to asses t...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1215 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of glioblastoma primary culture treated with TGF-beta receptor inhibition.
TGF-beta has an oncogenic response in glioblastoma and it is considered to be a therapeutic target. We evaluated the effect of TGF-beta inhibition in glioblastoma. Differential gene expression analysis of patient-derived primary cultured glioblastoma cells treated with the TGF-beta receptor inhibito...
ORGANISM(S): Homo sapiens 
2011-01-27 | E-GEOD-23935 | biostudies-arrayexpress
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