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TranscriptomicsDistinct Ldb1/NLI complexes orchestrate γ-globin repression and re-activation through ETO2 in human adult erythroid cells.
The Ldb1/GATA-1/TAL1/LMO2 complex mediates long range interaction between the β-globin locus control region (LCR) and gene in adult mouse erythroid cells but whether this complex mediates chromatin interactions at other developmental stages or in human cells is unknown. We investigated human NLI (Ld...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-30047 | biostudies-arrayexpress
TranscriptomicsUnexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
The mesencephalic dopaminergic (mDA) cell system is composed by two major groups of projecting cells in the Substantia Nigra (A9 neurons) and the Ventral Tegmental Area (A10 cells). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural reflexes. Th...
ORGANISM(S): Mus musculus 
2010-02-25 | E-GEOD-16192 | biostudies-arrayexpress
ProteomicsProteasome degradation of synthetic ubiquitinated globin
Analysis of the peptides resulting from proteasome-mediated degradation of K48-linked tetra ubiquitin conjugated to alpha globin
ORGANISM(S): Homo sapiens (Human) 
2021-08-24 | PXD004456 | Pride
Human 26s proteasome Alpha globin Ubiquitin 
TranscriptomicsTranscription profiling by array of whole blood from sickle-cell disease patients using globin mRNA reduction
Room temperature whole blood mRNA stabilization procedures, such as the PAX gene system, are critical for the application of transcriptional analysis to population-based clinical studies. Global transcriptome analysis of whole blood RNA using microarrays has proven to be challenging due to the high ...
ORGANISM(S): Homo sapiens 
2009-06-20 | E-GEOD-16728 | biostudies-arrayexpress
TranscriptomicsThe Effects of Globin on Microarray-based Gene Expression Analysis of Mouse Blood
Peripheral whole blood-based gene expression profiling has become one of the most common strategies exploited in the development of clinically relevant biomarkers. However, the ability to identify biologically meaningful conclusions from gene expression patterns in whole blood is highly problematic...
ORGANISM(S): Mus musculus 
2010-07-22 | E-GEOD-19282 | biostudies-arrayexpress
TranscriptomicsIncreased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA
Transcriptome analysis is of great interest in clinical research, where significant differences between individuals can be translated into biomarkers of disease. Although next generation sequencing provides robust, comparable and highly informative expression profiling data, with several million of ...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33701 | biostudies-arrayexpress
TranscriptomicsVariation in RNA-Seq transcriptome profiles of peripheral whole blood from healthy individuals with and without globin depletion
In this study we aimed to assess technical variability associated with globin depletion in addition to assessing general technical variability in RNA-Seq from whole blood derived samples. We compared technical and biological replicates having undergone globin depletion or not and found that globin d...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-53655 | biostudies-arrayexpress
TranscriptomicsComprehensive, high resolution analysis of cis-acting regulatory networks at the alpha globin locus (array)
We have combined the 4C chromosome conformation capture protocol with high throughput, genome-wide sequence analysis to characterise in full a cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10-1000kb), the 4C approach provides a comp...
ORGANISM(S): Homo sapiens 
2013-06-06 | E-GEOD-42383 | biostudies-arrayexpress
GenomicsZebrafish Globin Locus
This SuperSeries is composed of the following subset Series: GSE35874: Zebrafish Globin Locus (ChIP-seq) GSE35875: Zebrafish Globin Locus (DNAse) Refer to individual Series
ORGANISM(S): Danio rerio 
2012-02-17 | E-GEOD-35895 | biostudies-arrayexpress
GenomicsEpigenetic modifications and chromosome conformations of the beta globin locus throughout development
Human embryonic stem cells provide an alternative to using human embryos for studying developmentally regulated gene expression. The co-expression of high levels of embryonic epsilon and fetal gamma globin by the hESC-derived erythroblasts allows the interrogation of epsilon globin regulation at the...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-35375 | biostudies-arrayexpress
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