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ProteomicsDeep phenotyping of SH-Sy5y cells exposed to glucosylsphingosine by LC-MS
SH-Sy5y cells were exposed to glucosylsphingosine (GlcSph) at two concentrations observed in moderate (20 ng/mL) and severe (200 ng/mL) Gaucher disease phenotypes and subjected to label free proteomics to identify cellular pathways and molecules affected by GlcSph. Lyso-Gb3, a lipid accumulating in ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD061666 | Pride
Sh-sy5y Lc-ms Glucosylsphingosine Gaucher disease 
UnknownGlucosylsphingosine affects mitochondrial function in a neuronal cell model.
Not available
S-EPMC12371010 | biostudies-literature
UnknownPlasma Glucosylsphingosine in GBA1 Mutation Carriers with and without Parkinson's Disease.
Not available
S-EPMC8840974 | biostudies-literature
UnknownThe role of glucosylsphingosine as an early indicator of disease progression in early symptomatic type 1 Gaucher disease.
Not available
S-EPMC7876627 | biostudies-literature
UnknownOptic Nerve Lipidomics Reveal Impaired Glucosylsphingosine Lipids Pathway in Glaucoma.
Not available
S-EPMC6485987 | biostudies-literature
UnknownConsequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.
Not available
S-EPMC9058576 | biostudies-literature
UnknownGlucosylsphingosine Causes Hematological and Visceral Changes in Mice-Evidence for a Pathophysiological Role in Gaucher Disease.
Not available
S-EPMC5666873 | biostudies-literature
UnknownGlucosylsphingosine is a highly sensitive and specific biomarker for primary diagnostic and follow-up monitoring in Gaucher disease in a non-Jewish, Caucasian cohort of Gaucher disease patients.
Not available
S-EPMC3835853 | biostudies-literature
UnknownGlucosylsphingosine is a key biomarker of Gaucher disease.
Not available
S-EPMC5234703 | biostudies-literature
UnknownGlucosylsphingosine (Lyso-Gb1) as a reliable biomarker in Gaucher disease: a narrative review.
Not available
S-EPMC9926807 | biostudies-literature
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