Sort   by:  
 Page size 
MetabolomicsDevelopment of a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var to target glutamine dependency in cancer

The mitochondrial glutamine transporter SLC1A5_var plays a central role in the metabolic reprogramming of cancer cells by facilitating glutamine import into mitochondria for energy production and redox homeostasis. Despite its critical function, the development of effective and selective inhibito...

2025-08-13 | MTBLS12852 | MetaboLights
MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
TranscriptomicsThe gene expression response of MCF7 and MDAMB231 to glutamine deprivation
There are two major subtype of cells in breast cancer. These cancer cells response differently to glutamine deprivation, here we use one luminal type of breast cancer cell (MCF7) and one basal type of breast cancer cell (MDAMB231) to compare the gene expression differences of these two types of canc...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-26370 | biostudies-arrayexpress
GenomicsDNAJ-PKAc Induces Metabolic Rewiring and a Glutamine Dependency in Fibrolamellar HCC
DNAJ-PKAc Induces Metabolic Rewiring and a Glutamine Dependency in Fibrolamellar HCC
PRJNA1304424 | ENA
UnknownResistance to BRAF inhibitors induces glutamine dependency in melanoma cells.
Not available
S-EPMC4717845 | biostudies-literature
UnknownAlanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss.
Not available
S-EPMC10199906 | biostudies-literature
UnknownStretch stress propels glutamine dependency and glycolysis in optic nerve head astrocytes.
Not available
S-EPMC9389405 | biostudies-literature
UnknownTargeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis.
Not available
S-EPMC11866519 | biostudies-literature
ProteomicsMYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma
Multiple myeloma is an incurable hematological malignancy evolving from precursor states to advanced phases of the disease. MYC abnormalities play a critical role in the disease progression. Nevertheless, MYC lacks therapeutic drugability, thereby necessitating the exploration of alternative strateg...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD050010 | Pride
Tmt spectrometry Myc U266 Gls1 Nampt Gene dependency Myc overexpression Cellular metabolism Multiple myeloma 
Sort   by:  
 Page size