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MetabolomicsPersistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease

OBJECTIVES: Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism remain largely unknown. Herein, we apply ...

2020-01-22 | MTBLS729 | MetaboLights
ProteomicsGluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080779 | MassIVE
TranscriptomicsTranscription profiling of duodenum biopsies from patients with celiac disease taken at time of diagnosis or after two years of a gluten free diet
Study on the effects of long term, dietary, consumption of gliadin (gluten) in patients with celiac disease. Comparison of expression profiles of biopsies from normalized patients treated with gluten-free diet >2 years (FU-follow-up samples) versus biopsies from patients with active disease (Dx-at d...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-MEXP-1828 | biostudies-arrayexpress
ProteomicsTracking Gluten throughout Brewing Using N-Terminal Labeling Mass Spectrometry
Gluten-containing grains cause adverse health effects in individuals with celiac disease. Fermentation of these grains results in gluten-derived polypeptides with largely uncharacterized sizes and sequences, which may still trigger an immune response. This research used N-terminal labeling mass spec...
ORGANISM(S): Triticum aestivum (Wheat) Hordeum vulgare (Barley) Saccharomyces cerevisiae (Baker's yeast) 
2021-07-23 | PXD023482 | Pride
Barley Gliadin Brewing Gluten Celiac disease Beer Wheat 
ProteomicsDifferent Binding Motifs of the Celiac Disease Associated HLA Molecules DQ2.5, DQ2.2 and DQ7.5 Revealed by Relative Quantitative Proteomics of Endogenous Peptide Repertoires
In this study relative quantitative analysis of endogenous peptides by mass spectrometry combined with neural network analysis have been used to address why the alpha- or beta-chain sharing human leukocyte antigen (HLA)-DQ molecules DQ2.5, DQ2.2 and DQ7.5 display different risks for celiac disease. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080859 | MassIVE
TranscriptomicsTranscription profiling of intraepithelial and peripheral CTL from patients with celiac disease or cytomegalovirus seropositive patients suggest that a stepwise transformation of CTLs into NK-like cells may underlie immunopathology in various chronic infectious and inflammatory diseases.
Celiac disease is an intestinal inflammatory disorder induced by dietary gluten in genetically susceptible individuals. The mechanisms underlying the massive expansion of interferon g–producing intraepithelial cytotoxic T lymphocytes (CTLs) and the destruction of the epithelial cells lining the sm...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4592 | biostudies-arrayexpress
ProteomicsRye gluten characterisation - Rye, wheat and barley contain gluten, proteins that trigger immune-mediated inflammation of the small intestine in people with coeliac disease (CD)
Rye, wheat and barley contain gluten, proteins that trigger immune-mediated inflammation of the small intestine in people with coeliac disease (CD). The only treatment for CD is a lifelong gluten-free diet. To be classified as gluten-free by the World Health Organisation the gluten content must be b...
ORGANISM(S): Secale cereale 
2019-07-25 | PXD013459 | Pride
Prolamin Gluten Rye Lc-ms/ms 
ProteomicsComprehensive detection of isopeptides between human tissue transglutaminase and gluten peptides using a reciprocal proteomic approach
Celiac disease (CD) is a chronic inflammation of the small intestine triggered by the ingestion of gluten in genetically predisposed individuals. Tissue transglutaminase (TG2) is a key factor in the pathogenesis of CD, because it catalyzes both the deamidation of specific glutamine residues and the ...
ORGANISM(S): Homo sapiens (Human) Triticum aestivum (Wheat) 
2019-09-27 | PXD014067 | Pride
Celiac disease  transglutaminase  isopeptides  gluten 
ProteomicsValidation of N-terminal Labeling Mass Spectrometry for Characterization of Partially Hydrolyzed Gluten Proteins
Gluten, a group of proteins found in wheat, barley, and rye, is the trigger of celiac disease, an immune disorder which affects about 1% of people worldwide. The toxicity of partially hydrolyzed gluten (PHG) in fermented products such as beer is unknown due to the significant analytical challenges i...
ORGANISM(S): Triticum aestivum (Wheat) 
2019-11-20 | PXD012296 | Pride
Hydrolyzed gluten  gluten  mass spectrometry  n-terminal labeling  tails 
ProteomicsSpecific Non-Gluten Proteins of Wheat are Novel Target Antigens in Celiac Disease Humoral Response
While the antigenic specificity and pathogenic relevance of immunologic reactivity to gluten in celiac disease have been extensively researched, the immune response to non-gluten proteins of wheat has not been characterized. We aimed to investigate the level and molecular specificity of antibody re...
ORGANISM(S): Triticum Aestivum (ncbitaxon:4565) Specific Non-gluten Proteins Of Wheat Are Novel Target Antigens In Celiac Disease Humoral Response 
2014-10-05 | MSV000078884 | MassIVE
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