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ProteomicsCytochrome P450s protect against oxidative damage via a preferred orientation of the heme cofactor
Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenases that utilise a cysteine thiolate ligated heme moiety to perform a wide range of demanding oxidative transformations. Given the oxidative power of active intermediate formed within P450s during their active cycle, it is remarkable th...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030867 | Pride
Glycopeptide antibiotic (gpa) biosynthesis Cytochrome p450s 
ProteomicsElucidation of the substrate specificity of the ABC transporter Tba uncovers an unsuspected role in the biosynthesis of glycopeptide antibiotics
In this project, the proximal proteins of the balhimycin transporter Tba in A. balhimycina were investigated in order to elucidate potential interaction partners. Tba is an ABC transporter, which is co-encoded with biosynthetic enzymes in the biosynthetic gene cluster of the glycopeptide antibiotic ...
ORGANISM(S): Bacteria Amycolatopsis balhimycina 
2025-05-07 | PXD054387 | Pride
Amycolatopsis balhimycina Glycopeptide antibiotics Balhimycin Abc transporter 
UnknownThe Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis.
Not available
S-EPMC6929969 | biostudies-literature
UnknownAltering glycopeptide antibiotic biosynthesis through mutasynthesis allows incorporation of fluorinated phenylglycine residues.
Not available
S-EPMC11376024 | biostudies-literature
UnknownTrichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance.
Not available
S-EPMC6256792 | biostudies-literature
UnknownBiochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934.
Not available
S-EPMC5238595 | biostudies-literature
UnknownNew Molecular Tools for Regulation and Improvement of A40926 Glycopeptide Antibiotic Production in <i>Nonomuraea gerenzanensis</i> ATCC 39727.
Not available
S-EPMC6985074 | biostudies-literature
UnknownThe biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis.
Not available
S-EPMC6333238 | biostudies-literature
UnknownA rare peptide scaffold in kineomicins, the glycopeptide antibiotics produced by Actinokineospora auranticolor DSM 44650.
Not available
S-EPMC12049478 | biostudies-literature
UnknownA proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics.
Not available
S-EPMC6993612 | biostudies-literature
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