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ProteomicsMkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein -Total
Loss-of-function mutations in MKRN3 cause central precocious puberty, and our findings show that MKRN3 regulates GnRH production by binding the Gnrh1 3′UTR and altering subcellular localization of its precursor protein through post-transcriptional mechanisms. This function likely involves interactio...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-14 | PXD065897 | Pride
Mkrn3 Gnrh1 precursor protein 
ProteomicsMkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein - DIA cell fractions
Loss-of-function mutations in MKRN3 cause central precocious puberty, and our findings show that MKRN3 regulates GnRH production by binding the Gnrh1 3′UTR and altering subcellular localization of its precursor protein through post-transcriptional mechanisms. This function likely involves interactio...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-14 | PXD065908 | Pride
Dia Mkrn3 Gnrh1 precursor protein 
ProteomicsMkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein - Mkrn3-AP-MS
Loss-of-function mutations in MKRN3 cause central precocious puberty, and our findings show that MKRN3 regulates GnRH production by binding the Gnrh1 3′UTR and altering subcellular localization of its precursor protein through post-transcriptional mechanisms. This function likely involves interactio...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-14 | PXD065952 | Pride
Ap-ms Mkrn3 Gnrh1 precursor protein 
TranscriptomicsEffects of a short-term exposure to the fungicide prochloraz on endocrine function and gene expression in female fathead minnows (Pimephales promelas)
Prochloraz is a fungicide known to cause endocrine disruption through effects on the hypothalamic-pituitary-gonadal (HPG) axis. To determine the short-term impacts of prochloraz on gene expression and steroid production, adult female fathead minnows (Pimephales promelas) were exposed to the chemical...
ORGANISM(S): Pimephales promelas 
2011-02-03 | E-GEOD-26958 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human primary ovarian granulosa cells with knockdown of ESR2 isoform 1, treated with estradiol
ERβ1 is the predominant isoform mediating transcriptional activity in granulosa cells; however, ERβ1-specific target genes remain largely unknown. Here, we performed transcriptomic analysis of primary human granulosa cells with specific knockdown of ERβ1 and stimulation with estradiol (E2), an ERβ a...
ORGANISM(S): Homo sapiens 
2026-06-30 | E-MTAB-16651 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptomic profiling of a human liver-on-chip model across hypothermic preservation conditions: University of Wisconsin versus hyperbranched polyglycerol solution
This dataset contains single-cell RNA sequencing (scRNA-seq) data generated from a multicellular human liver-on-chip model to characterise cell-type-specific transcriptional responses to hypothermic preservation. The organ-on-chip system comprised four cell populations: patient-derived hepatic organ...
ORGANISM(S): Homo sapiens 
2026-04-17 | E-MTAB-16925 | biostudies-arrayexpress
TranscriptomicsOogenesis in Solea senegalensis: mature versus atretic ovaries
Transcriptionnal profile changes in ovary during the reproductive cycle of Solea senegalensis: from mature stage to atresia stage obtained at different times during the annual reproductive cycle. An oligo microarray based on ESTs sequenced from S. senegalensis previously designed (Cerdà et al., 200...
ORGANISM(S): Solea senegalensis 
2010-06-21 | E-GEOD-17335 | biostudies-arrayexpress
TranscriptomicsOogenesis in Solea senegalensis: Vitellogenic versus mature ovaries
Transcriptionnal profile changes in ovary during the reproductive cycle of Solea senegalensis: from vitellogenic stage to mature stage obtained at different times during the annual reproductive cycle. An oligo microarray based on ESTs sequenced from S. senegalensis previously designed (Cerdà et al....
ORGANISM(S): Solea senegalensis 
2010-06-21 | E-GEOD-17333 | biostudies-arrayexpress
TranscriptomicsOogenesis in Solea senegalensis: various developmental stages
This SuperSeries is composed of the following subset Series: GSE17333: Oogenesis in Solea senegalensis: Vitellogenic versus mature ovaries GSE17334: Oogenesis in Solea senegalensis: vitellogenic versus atretic ovaries GSE17335: Oogenesis in Solea senegalensis: mature versus atretic ovaries GSE17336:...
ORGANISM(S): Solea senegalensis 
2010-06-21 | E-GEOD-17337 | biostudies-arrayexpress
TranscriptomicsSuperovulation with eCG alone or combined with the GnRH analogue buserelin improves transferable embryo production in weaned sows without affecting embryo quality
The objective of this study was to evaluate the effects of eCG administered alone or in combination with buserelin (BU) on ovulatory response, embryo production efficiency, developmental synchrony, and blastocyst transcriptomic profiles in weaned donor sows. The experiment comprised six trials, each...
ORGANISM(S): Sus scrofa 
2026-09-07 | E-MTAB-16983 | biostudies-arrayexpress
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