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ProteomicsMkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein - Mkrn3-AP-MS
Loss-of-function mutations in MKRN3 cause central precocious puberty, and our findings show that MKRN3 regulates GnRH production by binding the Gnrh1 3′UTR and altering subcellular localization of its precursor protein through post-transcriptional mechanisms. This function likely involves interactio...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-14 | PXD065952 | Pride
Ap-ms Mkrn3 Gnrh1 precursor protein 
ProteomicsMkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein -Total
Loss-of-function mutations in MKRN3 cause central precocious puberty, and our findings show that MKRN3 regulates GnRH production by binding the Gnrh1 3′UTR and altering subcellular localization of its precursor protein through post-transcriptional mechanisms. This function likely involves interactio...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-14 | PXD065897 | Pride
Mkrn3 Gnrh1 precursor protein 
ProteomicsMKRN3 interacting proteins identified by LC-MS/MS
MKRN3, whose deletion or loss-of-function mutations were genetically associated with human centeral precocious puberty (CPP). To identify the potential substrates for MKRN3, MKRN3 was transfected into HEK293T cells as bait, and its interacting proteins were identified by mass spectrum and functions ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-22 | PXD022346 | Pride
Human Mkrn3 Hek293t Lc-ms/ms 
ProteomicsMkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein - DIA cell fractions
Loss-of-function mutations in MKRN3 cause central precocious puberty, and our findings show that MKRN3 regulates GnRH production by binding the Gnrh1 3′UTR and altering subcellular localization of its precursor protein through post-transcriptional mechanisms. This function likely involves interactio...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-14 | PXD065908 | Pride
Dia Mkrn3 Gnrh1 precursor protein 
GenomicsRNA Sequencing for MKRN3 regulating genes identification in GT1-7 cells
RNA Sequencing for MKRN3 regulating genes identification in GT1-7 cells
PRJNA673245 | ENA
ProteomicsProteomic Analysis of Mkrn3 WT vs KO mouse brain
Mutations in the E3 ubiquitin ligase Mkrn3 are associated with precocious puberty in humans. In order to determine the targets of Mkrn3, we performed a TMT-based proteomic analysis of Mkrn3 WT vs KO mouse brains.
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD027220 | Pride
Mouse Brain Tmt E3 ubiquitin ligase Precocious puberty 
GenomicsEffect of MKRN3 deletion on gene expression in hypothalamic neurons derived from human induced pluripotent stem cells (hiPSCs)
Effect of MKRN3 deletion on gene expression in hypothalamic neurons derived from human induced pluripotent stem cells (hiPSCs)
PRJNA860813 | ENA
TranscriptomicsRNA Sequencing for MKRN3 regulating genes identification in GT1-7 cells
Purpose: The deletion or loss-of-function of MKRN3 were genetically associated with human centeral precocious puberty (CPP).The goal of this study is to explore the global genes expression changes on MKRN3 overexpessing by high-throughput RNA sequencing analysis. Methods: The mRNA profiles of wild-t...
ORGANISM(S): Mus musculus 
2021-02-22 | GSE160467 | GEO
TranscriptomicsEffect of MKRN3 deletion on gene expression in hypothalamic neurons derived from human induced pluripotent stem cells (hiPSCs)
Makorin ring finger protein 3 (MKRN3) was identified as an inhibitor of puberty initiation with the report of loss-of-function mutations in association with central precocious puberty. To investigate the roles and mechanisms of action of MKRN3 within the human hypothalamus, we used hypothalamic neur...
ORGANISM(S): Homo sapiens 
2023-06-14 | GSE208722 | GEO
UnknownMKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons.
Not available
S-EPMC7410046 | biostudies-literature
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