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Aspergillus fumigatus is an angioinvasive fungal pathogen and the main etiologic agent causing invasive aspergillosis. Upon contact with human umbilical vein endothelial cells (HUVECs), this fungus induces cellular injury, inflammatory response and a pro-thrombotic phenotype. The pathogen molecules ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-22 | PXD002823 | Pride
More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus. The azole class of antifungals represent first line therapeutics for most of these infections however resistance is rising. Identification of novel antifungal targets that, when inhibited, sy...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2024-04-09 | PXD042616 | Pride
C57BL/6 WT mice were infected with 1x10^6 P. brasiliensis yeasts. After 8 weeks and 12 weeks of infection the animals were euthanized and the granulomatous lesions were recovered. Then, the animals cells were lysed with distilled water and the yeast cell recovered. Once isolated, the yeasts proteins...
ORGANISM(S): Paracoccidioides brasiliensis (strain Pb18) 
2023-10-23 | PXD040826 | Pride
C57BL/6 WT mice were infected with 1x10^6 P. brasiliensis yeasts. After 8 weeks and 12 weeks of infection the animals were euthanized and the granulomatous lesions were recovered. Then, the yeasts were recovered and cultivated in a rich medium. After cultivation the yeasts proteins were extracted, d...
ORGANISM(S): Paracoccidioides brasiliensis (strain Pb18) 
2023-10-23 | PXD040829 | Pride
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