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UnknownPNPLA6 mutations cause Boucher-Neuhauser and Gordon Holmes syndromes as part of a broad neurodegenerative spectrum.
Not available
S-EPMC3891450 | biostudies-literature
TranscriptomicsDissecting the in vivo metabolic potential of two human gut acetogens.
Fermenting microbial communities generate hydrogen: its removal through production of acetate, methane, or hydrogen sulfide modulates the efficiency of energy extraction from available nutrients in many ecosystems. We noted that pathway components for acetogenesis are more abundantly and consistentl...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2010-05-21 | E-GEOD-21906 | biostudies-arrayexpress
TranscriptomicsKey hub and bottleneck genes differentiate the macrophage response to virulent and attenuated Mycobacterium bovis
Mycobacterium bovis is an intracellular pathogen that causes tuberculosis in cattle. Following infection, the pathogen resides and persists inside host macrophages by subverting host immune responses via a diverse range of mechanisms. Here, a high-density bovine microarray platform was used to exami...
ORGANISM(S): Bos taurus 
2014-08-01 | E-GEOD-59774 | biostudies-arrayexpress
TranscriptomicsGene expression signature induced by 8 weeks of cigarette smoke exposure in the lung of BALB/c mice
To investigate the impact of cigarette smoke on lung gene expression, female BALB/c mice were obtained from Charles River at 6-8 weeks of age. Using a whole body exposure system (SIU48, PROMECH LAB AB, Vintrie, Sweden), mice (5 per group) were exposed to room air or the mainstream cigarette smoke of...
ORGANISM(S): Mus musculus 
2014-04-01 | E-GEOD-55127 | biostudies-arrayexpress
ProteomicsSMAD4-NFATc1 protein-protein interaction informed therapeutic vulnerability in SMAD4-deficient pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a median survival rate of approximately six months. While genetic profiling has uncovered common mutations in PDAC, developing targeted therapeutic strategies remains challenging. SMAD4 is frequently mutated o...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD067749 | Pride
Smad4 Pancreatic cancer 
ProteomicsSARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses
SARS-CoV-2 encodes numerous virulence factors, yet their precise mechanisms of action remain unknown. We provide evidence that the SARS-CoV-2 non-structural protein 15 (nsp15) enhances viral virulence by suppressing the production of viral double-stranded (dsRNA), a potent inducer of antiviral signa...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD056702 | Pride
Nsp15 Sars-cov-2 
ProteomicsApolipoprotein A-II Increases Cholesterol Efflux Capacity of Mature High-Density Lipoproteins Via the Apolipoprotein A-I C-terminus
Samples were processed using Global and Limited Proteolysis (LiP). Peptides and proteins were identified using MaxQuant (v1.6.17.0), then summarized using R package RomicsProcessor.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-29 | MSV000095479 | MassIVE
ProteomicsAnalysis of innate immune antagonism by SARS-CoV-2 reveals options for therapeutic immune modulation and differences to SARS-CoV
The novel coronavirus SARS-CoV-2 has rapidly caused a global pandemic, due to higher transmission rates and lower mortality than previous epidemic CoVs. Here, we systematically analysed changes in the proteome of HEK293 cells upon overexpression of key SARS-CoV-2 encoded proteins and compared them ...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2021-06-23 | PXD021899 | Pride
Sars-cov2 Innate immune system 
ProteomicsDepletion of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication
New therapeutic targets are a valuable resource in the struggle to reduce the morbidity and mortality associated with the COVID-19 pandemic. Genome-wide association studies (GWAS) have identified a number of risk loci but these include co-morbidities and are not specific to host-virus interactions. ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD031611 | Pride
Sars-cov-2 Viral replication Exosc2 
TranscriptomicsPriming defense genes and metabolites in hybrid poplar by the green leaf volatile cis-3-hexenyl acetate
• Herbivore-induced plant volatiles (HIPVs), in addition to attracting natural enemies of herbivores, can serve a signaling function within plants by acting as wound signals that induce or prime defenses. However, particularly in woody plants, which compounds within HIPV blends are capable of act...
ORGANISM(S): Populus x canadensis 
2010-05-25 | E-GEOD-11955 | biostudies-arrayexpress
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