In this study, we isolated secreted extracellular vesicles (EVs) from a Kenyan P. falciparum clinical isolate (referred to as 9605) adapted to in vitro culture for a short period and characterized their protein content by mass spectrometry.
The family of apicomplexa-specific proteins with DNA binding AP2 domains (ApiAP2s) includes sequence-specific transcription factors that are key regulators of development in malaria parasites. However, functions for the majority of ApiAP2 genes remain unknown. Here, a systematic knockout screen in P...
Chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infections and preventable blindness worldwide. There are, however, limited in vitro models to study the role of host genetics in the response of macrophages to this obligate human pathogen. Here, we describe an approach...
ORGANISM(S): Chlamydia trachomatis Homo sapiens (Human)
Bulk RNA-seq profiling of untreated human cell lines derived from blood, breast and bladder tissues (MCF7, MDA-MB-231, KMCB2, Jurkat) to characterise baseline transcriptional differences across cellular contexts.
