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ProteomicsiTRAQ analysis of K562 cell line
K562 cells untreated (S) and treated (S+IM) with Imatinib as well as sensitive (S+IM) and resistant (R) to imatinib were subjected to labelled quantification by iTRAQ to identify Bcr-Abl downstream signaling components and proteins modulated in resistance respectively
ORGANISM(S): Homo sapiens (Human) 
2021-10-05 | PXD025173 | Pride
K562 Itraq 
ProteomicsLC-MSMS of leukemic cell line K562
Comparative label free quantitative proteomic analysis using SWATH-MS has been carried out for K562 cells treated with Imatinib (S+IM) against untreated K562 (S) as well as imatinib resistant K562 cells (R). Compariosn of S+IM vs R constitutes Dataset 1 while that of S vs S+IM constitutes dataset 2
ORGANISM(S): Homo sapiens (Human) 
2019-06-14 | PXD009686 | Pride
K562 Swath-ms Lc-msms 
ProteomicsImmunoprecipitation followed by mass spectrometry (IP-MS)
Immunoprecipitation of ITGB1 and YWHAE was done to understand its interactive partners in K562/S cells. Mass spectrometry was performed to identify interactive molecules. Non-specific proteins (contaminants) such as keratins were excluded from the final analysis based on the results of the negative ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-30 | PXD056828 | Pride
Immunoprecipitation Mass spectrometry Protein-protein interaction Lc-ms/ms 
UnknownAtypical activation of signaling downstream of inactivated Bcr-Abl mediates chemoresistance in chronic myeloid leukemia.
Not available
S-EPMC8891420 | biostudies-literature
ProteomicsPhosphoproteome enrichment strategy using complementary chemistries of Fe-NTA and TiO2 followed by LC-MS/MS
The global phosphoproteome analysis by liquid chromatography-mass spectrometry (LC-MS) has emerged as an important tool to study cell signalling. However, the coverage of phosphoproteome by LC-MS is limited despite various approaches for phosphoprotein enrichment. Studies in literature have exploite...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050933 | Pride
Affinity chromatography Phosphoproteins Enrichment Lc-ms/ms 
TranscriptomicsGenomic profiling of immature hematopoietic cells to obtain insights into imatinib resistance
Chronic myeloid leukemia (CML) epitomizes successful targeted therapy, with 86% of patients in the chronic phase treated with tyrosine kinase inhibitors (TKIs) attaining remission. However, resistance to TKIs occurs during treatment, and patients with resistance to TKIs progress to the acute phase c...
ORGANISM(S): Homo sapiens 
2024-01-01 | E-MTAB-11899 | biostudies-arrayexpress
ProteomicsQuantitative comparative proteomic analysis of ITGB1-knockdown and ITGB1-vector control cells in K562/S
The global proteome analysis by liquid chromatography-mass spectrometry (LC-MS) has emerged as an important tool to study cell signalling. The effect of ITGB1 on imatinib resistance to leukemia was checked by comparing quantitative proteomic analysis of ITGB1-knockdown (ITGB1-KD) and ITGB1- vector c...
ORGANISM(S): Homo sapiens (Human) 
2025-10-30 | PXD057116 | Pride
Swath Lc-ms/ms. Proteomics 
ProteomicsPhosphoproteome enrichment strategy using complementary chemistries of Fe-NTA and TiO2 followed by LC-MS/MS
The global phosphoproteome analysis by liquid chromatography-mass spectrometry (LC-MS) has emerged as an important tool to study cell signalling. However, the coverage of phosphoproteome by LC-MS is limited despite various approaches for phosphoprotein enrichment. Studies in literature have exploite...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Cercopithecus aethiops (Green monkey) (Grivet) Pinus radiata (Monterey pine) Drosophila melanogaster (Fruit fly) Caenorhabditis elegans Dictyostelium discoideum (Slime mold) Cicer arietinum (Chickpea) (Garbanzo) Bos taurus (Bovine) Candida albicans (Yeast) Homo sapiens (Human) Brassica oleracea var. botrytis (Cauliflower) Bombyx mori (Silk moth) Brassica napus (Rape) 
2025-10-30 | PXD057032 | Pride
Affinity chromatography Phosphoproteins Enrichment Lc-ms/ms 
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