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TranscriptomicsGPBAR1 agonism has a broad impact on blocking macrophage activation
Human D14+ / CD16+ monocytes were treated with GPBAR1 agonists or controls, and were stimulated with interferon gamma and LPS. At 6 and 24 hours, the cells were profiled by RNAseq 40 total samples, 5 per group with eight groups. Individual donors used for multiple comparisons, so paired analysis ...
ORGANISM(S): Homo sapiens 
2014-06-10 | E-GEOD-57494 | biostudies-arrayexpress
TranscriptomicsGPBAR1 agonism has a broad impact on blocking macrophage activation
Human D14+ / CD16+ monocytes were treated with GPBAR1 agonists or controls, and were stimulated with interferon gamma and LPS. At 6 and 24 hours, the cells were profiled by RNAseq
ORGANISM(S): Homo sapiens 
2014-06-10 | GSE57494 | GEO
ProteomicsInvestigation of GPCR-G protein coupling by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) : the GPBAR1 case.
G protein-coupled receptors (GPCRs) are key classes of proteins for drug discovery research as many of them are still orphans and their function poorly known. Their activation mechanism is roughly divided in two states : active and unactive states however related dynamics to switch from one state to...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD047827 | Pride
Cryo-em Gpbar1 G protein Gpcr-g protein Tgr5 Hdx-ms Gpcr 
UnknownTargeted deletion of Gpbar1 protects mice from cholesterol gallstone formation.
Not available
S-EPMC1559456 | biostudies-literature
UnknownPatchouli alcohol inhibits GPBAR1-mediated cell proliferation, apoptosis, migration, and invasion in prostate cancer.
Not available
S-EPMC9732702 | biostudies-literature
UnknownImpaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling.
Not available
S-EPMC4503431 | biostudies-literature
UnknownNavigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands.
Not available
S-EPMC4933954 | biostudies-literature
UnknownGLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation.
Not available
S-EPMC8998127 | biostudies-literature
UnknownHarnessing the Estradienone Scaffold to Develop Dual GPBAR1 and LIFR Modulators for Liver Fibrosis.
Not available
S-EPMC12516728 | biostudies-literature
UnknownDeciphering molecular determinants of GPBAR1-Gs protein interactions by HDX-MS and cryo-EM.
Not available
S-EPMC12381156 | biostudies-literature
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