Werner syndrome (WS) is a human adult progeroid syndrome caused by loss-of-function mutations in the WRN RECQ helicase gene. We analyzed mRNA and miRNA expression in fibroblasts from WS patients and in fibroblasts depleted of WRN protein in order to determine the role of WRN in transcription regulat...
Triple-negative breast cancer (TNBC) lacks ER, PR and HER2 expression, represents ~10–20% of invasive breast cancers, and is clinically aggressive with limited targeted treatment options. Its pronounced molecular heterogeneity challenges single-marker diagnostics, motivating the development of robus...
Triple-negative breast cancer (TNBC) lacks ER, PR and HER2 expression, represents ~10–20% of invasive breast cancers, and is clinically aggressive with limited targeted treatment options. Its pronounced molecular heterogeneity challenges single-marker diagnostics, motivating the development of robus...
