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ProteomicsIntegrating Proteomics and Bioinformatics Methods for the Identification of Breast Cancer Biomarkers Interacting with Telomeric G-Quadruplex
The identification of reliable biomarkers is imperative for enhancing early detection, prognosis, and treatment of breast cancer. This study investigates a human telomeric dimeric G-quadruplex (G4) model, Tel46, which has been functionalized on Controlled Pore Glass (CPG) support, as a novel tool fo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059593 | Pride
Bioinformatics Telomeric g-quadruplex Proteomics Dna-protein interactions. Breast cancer biomarkers 
ProteomicsCombining proteomics and machine learning to identify potential triple negative breast cancer biomarkers binding telomeric G-Quadruplex
Triple-negative breast cancer (TNBC) lacks ER, PR and HER2 expression, represents ~10–20% of invasive breast cancers, and is clinically aggressive with limited targeted treatment options. Its pronounced molecular heterogeneity challenges single-marker diagnostics, motivating the development of robus...
ORGANISM(S): Homo sapiens (Human) 
2026-05-29 | PXD072866 | Pride
Aptamers Pulldown Cancer Tnbc Gquadruplex Tumor Triple negative breast cancer Human G4 
ProteomicsCombining proteomics and machine learning to identify triple negative breast cancer biomarkers binding telomeric G-Quadruplex
Triple-negative breast cancer (TNBC) lacks ER, PR and HER2 expression, represents ~10–20% of invasive breast cancers, and is clinically aggressive with limited targeted treatment options. Its pronounced molecular heterogeneity challenges single-marker diagnostics, motivating the development of robus...
ORGANISM(S): Homo sapiens (Human) 
2026-05-29 | PXD072964 | Pride
Tel46 Tnbc Gquadruplex Cancer Breast Dna Quantitative proteomics Biomarkes 
UnknownIntegrating proteomics and bioinformatics for the identification of breast cancer biomarkers interacting with telomeric G-quadruplex.
Not available
S-EPMC12403490 | biostudies-literature
ProteomicsIntegrating Proteomics and Bioinformatics Methods for the Identification of Breast Cancer Biomarkers Interacting with Telomeric G-Quadruplex
The identification of reliable biomarkers is imperative for enhancing early detection, prognosis, and treatment of breast cancer. This study investigates a human telomeric dimeric G-quadruplex (G4) model, Tel46, which has been functionalized on Controlled Pore Glass (CPG) support, as a novel tool fo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059597 | Pride
Bioinformatics Telomeric g-quadruplex Proteomics Dna-protein interactions. Breast cancer biomarkers 
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