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MetabolomicsTreatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics
Introduction: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. Objectives: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys10, Cys13) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obes...
2017-07-25 | MTBLS334 | MetaboLights
ProteomicsProteomic and metabolomic analysis of Nothapodytes nimmoniana (J. Graham) extracts treatment on HeLa cells
Nothapodytes nimmoniana is a natural source of camptothecin, a known anticancer drug. Stem and leaf extracts of Nothapodytes nimmoniana were studied to assess its in-vitro action on cancer progression events in a cervical cancer cell line, the HeLa. As a well-studied ideal model system, the HeLa has...
ORGANISM(S): Homo sapiens (Human) 
2020-04-07 | PXD017375 | Pride
Nothapodytes nimmoniana (j. graham) Anticancer Proteomics Metabolomics Rrlc-esi-qtofms Hela Camptothecin 
MetabolomicsOral dysbiosis initiates periodontal disease in experimental kidney disease

BACKGROUND AND HYPOTHESIS: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva ...

2025-09-04 | MTBLS1833 | MetaboLights
UnknownAlmond Snacking for 8 wk Increases Alpha-Diversity of the Gastrointestinal Microbiome and Decreases Bacteroides fragilis Abundance Compared with an Isocaloric Snack in College Freshmen.
Not available
S-EPMC6736066 | biostudies-literature
UnknownP-bodies directly regulate MARF1-mediated mRNA decay in human cells.
Not available
S-EPMC9303261 | biostudies-literature
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
TranscriptomicsRNA-seq transcriptome profiling of the psychrophilic diatom Fragilariopsis cylindrus grown at 0 degree Celsius and two levels of salinity
The data set described here complements data available under accession number E-MTAB-5153. We performed bulk RNA-sequencing experiments to examine gene expression in the genome of the cold-adapted (psychrophilic) marine diatom Fragilariopsis cylindrus growing at 0 degree Celsius and salinity of 34 ...
ORGANISM(S): Fragilariopsis cylindrus 
2022-04-30 | E-MTAB-8665 | biostudies-arrayexpress
MetabolomicsMetabolic differences in ripening of Solanum lycopersicum 'Ailsa Craig' and three monogenic mutants
Application of mass spectrometry enables the detection of metabolic differences between groups of related organisms. Differences in the metabolic fingerprints of wild-type Solanum lycopersicum and three monogenic mutants, ripening inhibitor (rin), non-ripening (nor) and Colourless non-ripening (Cnr)...
2014-02-07 | MTBLS36 | MetaboLights
UnknownIsotope-Filtered 4D NMR Spectroscopy for Structure Determination of Humic Substances.
Not available
S-EPMC4531828 | biostudies-literature
ProteomicsStructural proteomic analysis of folding intermediates of FLuc on the human ribosome
hRNC XL-MS: Protein biogenesis begins on the ribosome where nascent chains are expressed vectorially from their N- to C-terminus, and start to fold as mRNA is translated. How the context of protein synthesis influences protein folding is poorly understood, especially in eukaryotes. Here we describe ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD055251 | Pride
Human Ribosome Cotranslational Xl-ms Firefly luciferase Protein folding 
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