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UnknownPathological α-synuclein elicits granulovacuolar degeneration independent of tau.
Not available
S-EPMC12177994 | biostudies-literature
ProteomicsThe proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
By combining immunohistochemistry (IHC) and laser microdissection (LMD) we isolated neurons with GVD and those bearing tangles separately from human post-mortem AD hippocampus (n=12) using their typical markers casein kinase (CK)1δ and phosphorylated tau (AT8). Control neurons were isolated from cog...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023199 | Pride
Alzheimer´s disease Neurofibrillary tangles Granulovacuolar degeneration Tau Neuropathology Proteomics 
ProteomicsCasein kinase 1δ induces the formation of GVB-positive neurons that are resilient to tau-induced impairment of protein synthesis
The progressive intraneuronal accumulation of protein aggregates is central in the pathogenesis of several neurodegenerative diseases. Therefore, molecular pathways that mediate neuronal resilience to tau pathology present interesting targets for therapeutic intervention. To this end we investigated...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-09 | PXD061887 | Pride
Resilience Granulovacuolar degeneration bodies (gvbs) Tau Ck1δ 
UnknownGranulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles.
Not available
S-EPMC3037976 | biostudies-literature
UnknownUntangling the origin and function of granulovacuolar degeneration bodies in neurodegenerative proteinopathies.
Not available
S-EPMC7469111 | biostudies-literature
UnknownMitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology.
Not available
S-EPMC8048674 | biostudies-literature
UnknownPhosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles.
Not available
S-EPMC4298759 | biostudies-literature
UnknownGranulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology.
Not available
S-EPMC6851499 | biostudies-literature
UnknownThe proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease.
Not available
S-EPMC7882576 | biostudies-literature
UnknownIntraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation.
Not available
S-EPMC9376392 | biostudies-literature
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