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TranscriptomicsInvestigation of placental gene expression in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2019-01-31 | E-MTAB-6418 | biostudies-arrayexpress
TranscriptomicsInvestigation of placental DNA methylation in obese women exposed to Metformin during pregnancy
Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determin...
ORGANISM(S): Homo sapiens 
2018-11-01 | E-MTAB-6421 | biostudies-arrayexpress
ProteomicsPharmacological inhibition of the glucocorticoid regenerating enzyme 11ßhydroxysteroid dehydrogenase type 1 after myocardial infarction preserves cardiac function in a translational pig model
Background and Purpose: Adrenal glucocorticoids (GC) increase acutely after myocardial infarction (MI) and thereafter tissue levels are maintained selectively within cells expressing the enzyme 11ßHydroxysteroid Dehydrogenase type 1 (11ßHSD1) that regenerates active GC from circulating metabolites. ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-01-15 | PXD055401 | Pride
Heart Pig 
TranscriptomicsGenetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility.
This study investigates three radiation exposure scenarios in BALB/c and C57BL/6 mice: (1) low dose (LD) group -- four weekly doses of 7.5 cGy, (2) high dose (HD) group -- four weekly doses of 1.8 Gy, (3) unexposed group -- four weekly sham exposures. We then used comparative expression profiles of ...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-40066 | biostudies-arrayexpress
UnknownPostoperative rehospitalization in older surgical patients: an age-stratified analysis.
Not available
S-EPMC10286398 | biostudies-literature
TranscriptomicsGenome-wide transcriptomic analysis of the sporophyte of the moss Physcomitrella patens
Bryophytes are the most basal of the extant land plants. A major feature of these plants is the biphasic alteration of generations between a dominant haploid gametophyte and a minor diploid sporophyte phase. To analyse the differences in the transcriptome of the early gametophyte (protonema) and ear...
ORGANISM(S): Physcomitrella patens 
2013-07-29 | E-GEOD-32928 | biostudies-arrayexpress
TranscriptomicsLineage relationship in human dendritic cells - cDNA arrays
The lineage relationships and fate of human blood and tissue dendritic cells (DC) has significance for a number of diseases including HIV where both blood and tissue DC may be infected. We used gene expression profiling of monocyte and DC sub-populations sorted directly from blood and skin and compa...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-32648 | biostudies-arrayexpress
TranscriptomicsDNA methylation in postmortem brain samples from autism cases and controls
We used the Illumina 450KMethylation BeadChip to measure DNA methylation at 485,512 loci across the genome for 40 postmortem brain samples. The purpose of our study was to identify differentially methylated regions (DMRs) associated with autism. Samples included 16 temporal cortex brain tissue sampl...
ORGANISM(S): Homo sapiens 
2013-12-12 | E-GEOD-53162 | biostudies-arrayexpress
TranscriptomicsLineage relationship in human dendritic cells
The lineage relationships and fate of human blood and tissue dendritic cells (DC) has significance for a number of diseases including HIV where both blood and tissue DC may be infected. We used gene expression profiling of monocyte and DC sub-populations sorted directly from blood and skin and compa...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-32400 | biostudies-arrayexpress
ProteomicsA non-canonical SWI/SNF complex underlies synthetic lethality in cancers driven by BAF complex perturbation
Mammalian SWI/SNF chromatin remodeling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF, and a newly characterized non-canonical complex, ncBAF. However, their complex-specific targeting on chromatin, functions and roles in disease remain largely unknown. Here, we...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD011103 | Pride
Brd7 Mswi/snf Chromatin remodeling Brd9 Baf Dpf2 
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