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TranscriptomicsHeLa E2F1 ChIP-chip experiments
These are three biological replicates. HeLa cells were crosslinked on separate days. In each case, a matched total from the same crosslinking was produced in parallel. Amplicons were made from each and hybridized onto ENCODE region tiling arrays. Two color arrays were used; ChIP was red, Total was g...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4306 | biostudies-arrayexpress
TranscriptomicsTumor Liver vs Normal Liver: ChIP-chip and RNA expression
There is widespread interest in efficient characterization of differences between tumor and normal samples. Here, we demonstrate an effective methodology for genome-scale characterization of tumors. Using matched normal and tumor samples from liver cancer patients, as well as non-cancer-related nor...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10842 | biostudies-arrayexpress
TranscriptomicsDistinct transcriptional outputs associated with mono- and di-methylated histone H3 arginine 2
Dimethylation of histone H3 arginine 2 (H3R2me2) maintains transcriptional silencing by inhibiting Set-1 mediated trimethylation of H3K4. Here we demonstrate that arginine 2 is also monomethylated (H3R2me1) in yeast but that its functional characteristics are distinct from H3R2me2: (a) H3R2me1 does ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-06 | E-GEOD-14453 | biostudies-arrayexpress
Unknown6-methoxyflavanones as bitter taste receptor blockers for hTAS2R39.
Not available
S-EPMC3983201 | biostudies-literature
TranscriptomicsBCL6 ChIP on chip using a Nimblegen custom tiling array
To determine whether BCL6 binds to the certain locus we performed genomic localization studies by chromatin immunoprecipitations (ChIP) using a densely tiled custom oligonucleotide microarray covering the genomic loci of different genes. Keywords: ChIP-chip, Transcription Factor localization The ex...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-7673 | biostudies-arrayexpress
TranscriptomicsIgG control ChIP in HeLa cells
Control IgG ChIP vs matched total for HeLa cells. Three biological replicates. ChIP-chip of IgG; look for non-specific binding sites.
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4338 | biostudies-arrayexpress
TranscriptomicsPOLII localization in HeLa cells
RNA polymerase II (POLR2A; POLII) was localized via ChIP-chip using N20 Ab-mediated pull-down of POLII Classical design; ChIP-chip of POLII in ENCODE regions
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4337 | biostudies-arrayexpress
TranscriptomicsMYC binding sites in HeLa cells
MYC binding sites determined in HeLa cells using ChIP-chip ChIP-chip
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4354 | biostudies-arrayexpress
TranscriptomicsA computational genomics approach to identify cis-regulatory modules - a case study using E2F1
We first trained a set of experimentally identified E2F1 targets by a ChIPModules approach, the identified module of E2F1 and AP-2alpha was validated by ChIP-chip assays. We have performed 3 sets of ChIP-chip experiments in MCF-7 for E2F1 and AP-2alpha respectively. The common genes bound by both E2...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5175 | biostudies-arrayexpress
TranscriptomicsGenome-wide copy number analysis of patient-derived gliobastoma cell cultures
Genome-wide copy number variation profiles were analyzed in the patient-derived gliobastoma cell culture samples. For this purpose, gDNA was analyzed using the CytoScan® assay in combination with a one-color based labeling and hybridization protocol. Signals on the CytoScan® HD microarrays were dete...
ORGANISM(S): Homo sapiens 
2019-02-28 | E-MTAB-7649 | biostudies-arrayexpress
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