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ProteomicsAn NPAS4:NuA4 complex couples synaptic activity to DNA repair
Neuronal activity is critical for adaptive circuit remodeling but poses an inherent risk to the stability of the genome across the long lifespan of post-mitotic neurons1-5. Whether neurons have acquired specialized genome protection mechanisms that enable them to withstand decades of potentially dam...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-02-15 | PXD038718 | Pride
Nua4 Mus musculus Hippocampus Tip60 Hek293t Npas4 
TranscriptomicsSensory experience restricts cortical plasticity by inducing IGF-1 in VIP neurons
RNA-seq libraries purified from the visual cortices of neurons expressing Emx-, GAD2-, PV-, SST-, or VIP-Cre using the Ribotag allele. Seq libraries are provided from mice raised in standard housing, or housed in the dark for two weeks (dark-housed), or dark-housed and then exposed to light for 1, ...
ORGANISM(S): Mus musculus 
2016-03-17 | E-GEOD-77243 | biostudies-arrayexpress
GenomicsWidespread transcription at neuronal activity-regulated enhancers
We used genome-wide sequencing methods to study stimulus-dependent enhancer function in neurons. We identified ~12,000 neuronal activity-regulated enhancers that are bound by the general transcriptional co-activator CBP in an activity-dependent manner. A function of CBP at enhancers may be to recrui...
ORGANISM(S): Mus musculus 
2010-04-14 | E-GEOD-21161 | biostudies-arrayexpress
UnknownGERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder.
Not available
S-EPMC6214451 | biostudies-literature
TranscriptomicsKDM5C safeguards the appropriate timing of early neurodevelopment
We generated human induced pluripotent cells from intellectual disability patients carrying the c.2T>C mutation in KDM5C (Called “Mutant”). We generated a paired, isogenic human iPS cell line (called “Corrected”) using CRISPR/Cas9 and PiggyBac gene-editing technologies and conducted neuronal differe...
ORGANISM(S): Homo sapiens 
2023-10-13 | E-MTAB-7551 | biostudies-arrayexpress
UnknownComprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer.
Not available
S-EPMC5687509 | biostudies-literature
UnknownHeterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials.
Not available
S-EPMC10980745 | biostudies-literature
UnknownEfficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Not available
S-EPMC8693692 | biostudies-literature
UnknownMortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study.
Not available
S-EPMC8314066 | biostudies-literature
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
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