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ProteomicsThe effect of GLP-1 receptor agonist liraglutide on the rat neurointermediate lobe phosphoproteome
Obesity and its co-morbidities, such as diabetes and hypertension, can significantly reduce a person’s quality of life and place huge pressure on healthcare resources. When we eat a meal our gut and brain release hormones to control the amount of food and fluid we ingest to prevent overeating. One o...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-02 | PXD037495 | Pride
Phosphoproteomics Lc-msms Liraglutide Posterior pituitary Pituitary gland Intermediate lobe Phosphorylation 
UnknownPerformance of the pooled cohort equations and D:A:D risk scores among individuals with HIV in a global cardiovascular disease prevention trial: a cohort study leveraging data from REPRIEVE.
Not available
S-EPMC11890582 | biostudies-literature
ProteomicsSpatial multiomic analysis of synthesis, transport and secretion in the hypothalamus-neurohypophysial system
The cell bodies of hypothalamic magnocellular neurones (MCNs) are confined to the hypothalamic supraoptic nucleus (SON) whereas their axons project to the anatomically discrete posterior pituitary gland (PP). We have taken advantage of this unique anatomical structure to document proteome and phosph...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-13 | PXD033401 | Pride
Son Posterior pituitary Vasopressin Proteome Rat Phosphoproteome 
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
UnknownOpioids modulate an emergent rhythmogenic process to depress breathing.
Not available
S-EPMC6938398 | biostudies-literature
ProteomicsTranslational and post-translational dynamics in a model peptidergic system
The cell bodies of hypothalamic magnocellular neurones are densely packed in the hypothalamic supraoptic nucleus whereas their axons project to the anatomically discrete posterior pituitary gland. We have taken advantage of this unique anatomical structure to establish proteome and phosphoproteome d...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-12 | PXD040870 | Pride
Cytoskeleton Phosphoproteome Posterior pituitary Supraoptic nucleus Proteome 
ProteomicsGeneral anaesthesia leads to phosphoproteome changes in proteins involved in cytoskeleton remodelling and synaptic processes in the supraoptic nucleus of the hypothalamus
Despite the widespread use of general anaesthetics, the mechanisms mediating their effects are still not understood. Although suppressed in most parts of the brain, neuronal activity, as measured by FOS activation, is increased in the hypothalamic supraoptic nucleus (SON) by numerous general anaesth...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-23 | PXD039391 | Pride
Synapse Cytoskeleton Anaesthetic Phosphorylation Rat Supraoptic Lc-msms 
ProteomicsMultiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation
The one-humped Arabian camel (Camelus dromedarius) is the most important livestock animal in arid and semi-arid regions and continues to provide basic necessities to millions of people. In the current context of global warming, there is renewed interest in the adaptive mechanisms that enable camelid...
ORGANISM(S): Camelus dromedarius (Dromedary) (Arabian camel) 
2021-06-21 | PXD025644 | Pride
Desert physiology Camelus dromedarius Dromedary camel Kidney transcriptomics Countercurrent multiplication Kidney proteomics Water deprivation 
UnknownUse of a Cardiac Scale to Predict Heart Failure Events: Design of SCALE-HF 1.
Not available
S-EPMC10180020 | biostudies-literature
UnknownHousehold Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children-California and Colorado, 2021.
Not available
S-EPMC9015725 | biostudies-literature
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