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ProteomicsHigh throughput microfluidic 3D biomimetic model enabling quantitative description of human breast tumor microenvironment
Cancer is driven by genetic aberrations in the tumor cells and fundamental changes in the tumor microenvironment (TME). These changes offer potential targets for novel therapeutics, yet lack of in vitro 3D models recapitulating this complex microenvironment impedes such progress. Here, we generated ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD021509 | Pride
Breast cancer Microfluidics Tumor microenvironment Proteomic profiling Alginate 
ProteomicsNew mixture models for decoy-free false discovery rate estimation in mass-spectrometry proteomics
We introduce a new decoy-free framework for false discovery rate (FDR) estimation that generalizes present decoy-free approaches (DFAs) while exploiting more search data in a manner similar to target-decoy approaches (TDAs).
ORGANISM(S): Homo sapiens (Human) 
2020-01-10 | PXD020322 | Pride
Proteomics Decoy-free framework False discovery rate Bioinformatics 
ProteomicsImproved sensitivity of ultra-low flow LC-MS-based proteomic profiling of limited samples using monolithic capillary columns and FAIMS technology
In this work, we pioneered a combination of ultra-low flow (ULF) high-efficiency ultra-narrow bore monolithic LC columns coupled to MS via a high-field asymmetric waveform ion mobility spectrometry (FAIMS) interface to evaluate the potential applicability for high sensitivity, robust and reproducibl...
ORGANISM(S): Homo sapiens (Human) 
2021-01-10 | PXD020669 | Pride
Faims Lc-ms Proteomic analysis Ultra-low flow lc Monolithic column 
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