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TranscriptomicsRegulatory T cell-mediated resolution of lung injury: Identification of potential target genes via expression profiling
We examined early and late gene expression changes using the IT LPS model of Acute Lung Injury (ALI). In this model, injury peaks at day 4 and is almost completely resolved by day 10 in wild type (WT) C57BL/6 mice. In contrast to the pattern in WT mice, lymphocyte-deficient Rag-1 -/- mice exhibit ...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-17355 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung to investigate effects of ischemia reperfusion injury or nephrectomy
Experiments in rodents have shown that kidney ischemia/reperfusion injury (IRI) facilitates lung injury and inflammation. To identify potential ischemia-specific lung molecular pathways involved, we conducted global gene expression profiling of lung 6 or 36 hours following 1) bilateral kidney IRI, 2...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6730 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver to identify the effect of intermittent hypoxia on gene expression in the liver of ob/ob mice
All animals were kept in a controlled environment (22-24 °C with a 12 h : 12 h light : dark cycle; lights on at 09.00) on a standard chow diet with free access to water. Five ob/ob mice (sample_ids GSM32865-GSM32869) were placed in the intermittent hypoxia (IH) chamber and subjected to IH for 12 con...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-1873 | biostudies-arrayexpress
TranscriptomicsChronic Intermittent Hypoxia Increases Alveolar Surface Area in Adult Mice
Obstructive sleep apnea (OSA) leads to increased cardiovascular morbidity and mortality, which have been attributed to intermittent hypoxia (IH). The effects of IH on lung structure and function are unknown. We used a mouse model of chronic IH, which mimics the O2 profile in patients with OSA. We ex...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-21409 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of kidney infiltrating T cells after ischemia reperfusion injury reveals a pathophysiologic role for the chemokine (C-C motif) receptor 5
We examined the transcriptional responses in kidney infiltrating T cells 6 hrs after IRI CD3 (+) T cells were purified applying magnetic beads to mononuclear cells extracted from kidney by percoll gradient methods. The total T-cell RNA was isolated, and trabscript abundance measured with array-based...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-23747 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung after ventilator induced injury reveals genetic and pharmacologic evidence links oxidative stress
RATIONALE: Mechanical ventilation (MV) is an indispensable therapy for critically ill patients with acute lung injury and the adult respiratory distress syndrome. However, the mechanisms by which conventional MV induces lung injury remain unclear. OBJECTIVES: We hypothesized that disruption of the g...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9208 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung samples from mouse and rat treated with mechanical ventilation
This series contain mouse and rat lung samples treated with mechanical ventilation and corresponded controls.
ORGANISM(S): Mus musculus 
2007-07-20 | E-GEOD-2368 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung samples treated with Simvastatin and LPS and corresponded controls
This series contain mouse lung samples treated with Simvastatin and LPS and corresponded controls.
ORGANISM(S): Mus musculus 
2007-11-09 | E-GEOD-1871 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat mechanically ventilated lungs from strains resistant or susceptible to ventilation-associated lung injury (VALI)
We sought to confirm the genetic influence in the development of Ventilation-Associated Lung Injury (VALI) and, in the process, identify potential candidate genes involved in the disease by integrating differential gene expression profiling on rat lungs to a traditional strain survey analysis of the...
ORGANISM(S): Rattus norvegicus 
2007-10-31 | E-GEOD-7041 | biostudies-arrayexpress
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