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TranscriptomicsRNA polymerase is poised for activation across the genome
Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA ...
ORGANISM(S): Drosophila melanogaster 
2007-11-11 | E-GEOD-6714 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of TLR4 pathways in a murine model of chronic pulmonary inflammation and carcinogenesis
Toll like receptor 4 (TLR4), an innate immunity gene, is involved in responses to several pulmonary agonists including endotoxin (LPS; Poltorak et al.,1998), ozone (O3 ,Kleeberger et. al., 2001), Pseudomonas aeruginosa (Faure et al, 2004), and hyperoxia (Zhang et al, 2005). TLR4 appears to partially...
ORGANISM(S): Mus musculus 
2009-12-12 | E-GEOD-8504 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild-type and TTP-deficient fibroblast cell lines to identify TTP mRNA targets
Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice, and cells derived from them, showed that TTP could bind to certain AU-rich elements in mRNAs, leading to increases in the rates of mRN...
ORGANISM(S): Mus musculus 
2008-11-22 | E-GEOD-5324 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse uteri to evaluate the mechanism and physiological effects of estren
A proposed membrane-mediated mechanism of rapid non genomic response to estrogen has been the intense focus of recent research. Estren (Es), a synthetic steroid, is reported to act selectively through a rapid membrane-mediated pathway, rather than through the classical nuclear estrogen receptor (ER...
ORGANISM(S): Mus musculus 
2008-06-22 | E-GEOD-4615 | biostudies-arrayexpress
no omics definedTranscription profiling of human U-2 osteosarcoma cell lines expressing different glucocorticoid receptor isoforms - time series
Glucocorticoids regulate diverse physiologic processes and synthetic derivatives of these natural hormones are widely used in the treatment of inflammatory diseases. However, chronic administration often triggers insensitivity and serious side effects including osteoporosis. The underlying mechanis...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6711 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung carcinome calls treated WITH Farnesol reveals Farnesol-induced apoptosis IS coupled TO THE endoplasmic reticulum (ER) stress response
Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which these isoprenoids mediate their effects are not yet fully understood. In this study, we show that FOH is effective inducer of...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7215 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse thymocytes from ild type or RORg-/- animals
Microarray analysis was performed in order to identify changes in gene expression in thymocytes isolated from RORg-/- mice in comparison to those of wild type mice. Experiment Overall Design: Microarray analyses were carried out by the NIEHS Microarray Group (NMG). Gene expression analysis was condu...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4248 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse uterus exposed to DES reveals altered uterine gene expression that maybe associated with neoplasia later in life
Previously, we described a mouse model where the well-known reproductive carcinogen, diethylstilbestrol (DES), caused uterine adenocarcinoma following neonatal treatment. Tumor incidence was dose-dependent reaching >90% by 18 mo. following 1000 µg/kg/day of DES. These tumors followed the initiation...
ORGANISM(S): Mus musculus 
2008-11-06 | E-GEOD-5825 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild type (WT), RORalphasg/sg, RORgamma-/-, and double knockout animals reveals a regulatory role for RORalpha and RORgamma in Phase I and Phase II Metabolism
Retinoid-related orphan receptors RORalpha and RORgamma are both expressed in liver; however, their physiological functions have not yet been clearly defined. RORalpha1 and RORgamma1, but not RORalpha4, show an oscillatory pattern of expression during circadian rhythm. To obtain insight into the phy...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7564 | biostudies-arrayexpress
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