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ProteomicsA red blood cell-based antigen delivery system to facilitate T cell epitope presentation to induce peripheral tolerance to ADAMTS13 in immune-mediated TTP
Aims Leveraging the tolerogenic nature of their natural clearance pathway, we aim to exploit red blood cells (RBCs) as an antigen delivery system to achieve persistent exposure to ADAMTS13-derived peptides, promoting antigen-specific attenuation of autoreactive CD4+ T cells and induction of regulato...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD064980 | Pride
Adamts13 Ittp Immunopeptidomics Antigen presentation 
ProteomicsThe endothelial inflammatory repertoire: a multi-omic delineation of cytokine induced endothelial inflammatory states
Vascular endothelial cells (ECs) form a dynamic interface between blood and tissue and play a crucial role in the progression of vascular inflammation. Here, we explored the underlying molecular mechanisms of endothelial-cytokine responses which govern inflammation. Applying an unbiased cytokine lib...
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD036582 | Pride
Mult-omics Inflammation Endothelial cells 
ProteomicsEndothelial Colony Forming Cells Characteristics in a healthy and VWD patient cohort.
Background Endothelial cells are crucial for hemostasis as they produce Von Willebrand factor (VWF). Von Willebrand Disease (VWD) results from a deficiency or defects in VWF, However, diagnosis is difficult due to large differences between gene variants and bleeding phenotype. Here, we analyze the e...
ORGANISM(S): Homo sapiens (Human) 
2024-11-28 | PXD055124 | Pride
Proteomics Endothelial cell Ecfc Vwd 
ProteomicsIntegrative phosphoproteomic analysis reveal hemstatic-endothelial singaling internplay
The vascular endothelial cell (EC) monolayer plays a crucial part in maintaining hemostasis. An extensive array of G protein-coupled receptors (GPCRs) allows ECs to dynamically act on key hemostatic stimuli such as thrombin and histamine. The impact of these individual stimuli on EC signal transduct...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD055122 | Pride
Phosphoproteomics Endothelial cell Histamine Thrombin 
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