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TranscriptomicsLim Homeobox Gene, LHX8, Is Essential for Mouse Oocyte Differentiation and Survival
Lhx8 is a member of the LIM-homeobox transcription factor family and preferentially expressed in oocytes and germ cells within the mouse ovary. We discovered that Lhx8 knockout females lose oocytes within 7 days after birth. At the time of birth, histological examination shows that Lhx8 deficient (L...
ORGANISM(S): Mus musculus 
2008-06-25 | E-GEOD-11897 | biostudies-arrayexpress
ProteomicsDeficiency of OGT-mediated O-GlcNAcylation causes female infertility with oocyte meiotic arrest and follicle development defects by impairing mitochondrial function
Abnormalities in oocyte meiosis are a major cause of female infertility. Since transcriptional activity is largely absent during oocyte meiosis, post-translational modifications of proteins play an essential regulatory role. Among these, OGT-mediated O-GlcNAcylation is a key modification involved in...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-31 | PXD071809 | Pride
Ogt  o-glcnacylation  female infertility  oocyte  mitochondrial function 
ProteomicsDeficiency of OGT-mediated O-GlcNAcylation causes female infertility with oocyte meiotic arrest and follicle development defects by impairing mitochondrial function
Abnormalities in oocyte meiosis are a major cause of female infertility. Since transcriptional activity is largely absent during oocyte meiosis, post-translational modifications of proteins play an essential regulatory role. Among these, OGT-mediated O-GlcNAcylation is a key modification involved in...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-31 | PXD071865 | Pride
Ogt  o-glcnacylation  female infertility  oocyte  mitochondrial function 
TranscriptomicsLow dose human chorionic gonadotropin hCG
Influence of ovarian stimulation with 200 IU of hCG, (administered in the late follicular phase among ICSI patients undergoing a GnRH-antagonist protocol), on the endometrium on the day of oocyte pick-up. The purpose of the present study is to assess the influence of the administration of low dose h...
ORGANISM(S): Homo sapiens 
2010-10-02 | E-GEOD-18557 | biostudies-arrayexpress
ProteomicsTBP2/TFIIA complex drives an oocyte-type promoter usage grammar leading to female germ cell specific mRNA and endogenous retroviral element transcription
The transcriptional machinery involved in RNA polymerase II (Pol II) transcription during oogenesis is not well characterized. In somatic cells, the Pol II general transcription factor, TFIID, containing the TATA binding protein (TBP) and 13 TBP-associated factors, is the first to bind gene promoter...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-16 | PXD016347 | Pride
Tbpl2 Mouse Tfiia Growing oocyte 
TranscriptomicsGene expression profile of Dicer-deficient oocytes
Small RNAs, such as miRNAs and siRNAs, are involved in gene regulation in a variety of systems, including mouse oocytes. Dicer is a ribonuclease III enzyme essential for miRNA and siRNA biosynthesis. In an effort to uncover the function of small RNAs during oocyte growth, we specifically deleted Dic...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-17985 | biostudies-arrayexpress
ProteomicsOocyte-specific knockout of eIF2 subunits causes apoptosis of mouse oocytes within the early growing follicles via mitochondrial dysfunctions and DNA damage
For proteomic analysis, total protein was extracted from 3000 oocytes of each genotype and then analyzed by PTM-biolab (China).
ORGANISM(S): Mus Musculus 
PXD054478 |
UnknownGrowing microtubules push the oocyte nucleus to polarize the Drosophila dorsal-ventral axis.
Not available
S-EPMC3459055 | biostudies-literature
ProteomicsExploration on the Mechanism of Decreased Quality of Aging Oocytes After Ovulation
Decreased oocyte developmental potential is an important factor affecting fertility and embryonic development. Increasingly evidence is suggested that the decline in oocyte quality caused by aging after in vitro ovulation is a limiting factor affecting the development of assisted reproductive techno...
ORGANISM(S): Mus Musculus 
2022-11-23 | PXD038293 |
ProteomicsXenopus laevis oocyte mitochondria
Characterization of mitochondria in non-growing oocytes from xenopus laevis.
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-05-09 | PXD025366 | Pride
Oocytes Mitochondria 
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