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ProteomicsAnalysis of L1CAM-regulated signaling pathways and cellular responses to anti-L1CAM radioimmunotherapy in human ovarian cancer cells
L1 cell adhesion molecule (L1CAM) is overexpressed in various solid tumors, and its overexpression is linked to increased invasion, metastasis, angiogenesis, cancer stemness, and therapy resistance. However, the mechanisms of L1CAM-mediated carcinogenesis and radioresistance, particularly in high-gr...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD055521 | Pride
Tmt Human ovarian cancer L1cam Phosphoproteomics Radioimmunotherapy 
ProteomicsCancer responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)
The vast majority of our knowledge regarding cancer radiobiology and the activation of radio-resistance mechanisms emerged from studies using external beam radiation therapy (EBRT). Yet, less is known about the cancer response to internal targeted radionuclide therapy (TRT). Our comparative proteomi...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD036034 | Pride
Human Cancer Proteomics Radioresistance Phosphoproteomics Minigastrin 
ProteomicsSignaling network response to alpha-particle targeted therapy with actinium-225 labeled minigastrin analogue 225Ac-PP-F11N
Alpha-particle emitters have recently been explored as valuable therapeutic radionuclides. Yet, toxicity to healthy organs and cancer radioresistance limit the efficacy of targeted alpha-particle therapy (TAT). Identification of the radiation-activated mechanisms, which drive cancer cell survival, p...
ORGANISM(S): Homo sapiens (Human) 
2023-06-02 | PXD039033 | Pride
Human Cancer Proteomics Radioresistance Phosphoproteomics Minigastrin 
ProteomicsAnalysis of signaling networks in response to radioimmunotherapy in T-cell lymphoma mouse model
Cutaneous T-cell lymphomas (CTCLs) constitute a rare and heterogeneous group of lymphoid malignant neoplasms that initially involve the skin and are considered neglected clinical entities with very limited therapeutic options. Lymphoma cells (both B and T-cells) are extremely radiosensitive compared...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD053937 | Pride
Lymphoma Terbium-161 Tmt Phosphoproteomics Radioimmunotherapy 
TranscriptomicsGene expression profiling of human gliomas and human glioblastoma cell lines
To identify signaling pathways that are differentially regulated in human gliomas, a microarray analysis on 30 brain tumor samples (12 primary glioblastomas (GBM), 3 secondary glioblastomas (GBM-2), 8 astrocytomas (Astro) and 7 oligodendrogliomas (Oligo)) and on 5 glioblastoma cell lines (LN018, LN...
ORGANISM(S): Homo sapiens 
2011-03-18 | E-GEOD-15824 | biostudies-arrayexpress
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