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UnknownAssociation of Cognitive Frailty With Subsequent All-Cause Mortality Among Middle-Aged and Older Adults in 17 Countries.

Objectives

Cognitive frailty refers to the co-occurrence of cognitive impairment and frailty without concurrent Alzheimer's disease or dementia. Studies of cognitive frailty and mortality have been limited to single country or older people. However, frailty and cognitive decline may occur mu...
S-EPMC11710977 | biostudies-literature
UnknownAcupuncture as an early treatment for idiopathic sudden sensorineural hearing loss (ISSNHL) patients with flat or high-frequency drop audiograms: study protocol for a randomized controlled trial.

Background

Idiopathic sudden sensorineural hearing loss (ISSNHL) is a common form of deafness. Acupuncture has been used as a salvage therapy for ISSNHL in China since 200 BCE. However, the efficacy of acupuncture has not been confirmed in strictly controlled trials. We designed a randomized...
S-EPMC6032598 | biostudies-literature
UnknownStudy of sequence variation of dengue type 3 virus in naturally infected mosquitoes and human hosts: implications for transmission and evolution.
Dengue virus is an arbovirus that replicates alternately in the mosquito vector and human host. We investigated sequences of dengue type 3 virus in naturally infected Aedes aegypti mosquitoes and in eight patients from the same outbreak and reported that the extent of sequence variation seen with th...
S-EPMC525091 | biostudies-literature
ProteomicsProteomic analysis of human Sertoli cells-derived extracellular vesicles
We performed a proteomic analysis of EVs derived from human Sertoli cells, aiming to obtain the profiling of the proteins in these EVs to explore their possible roles in the development of testis.
ORGANISM(S): Homo sapiens (Human) 
2021-12-24 | PXD030640 | Pride
Extracellular vesicles Sertoli cells Spermiogenesis 
ProteomicsProteomic analysis of bovine milk-derived extracellular vesicles isolated via salting-out
We developed a novel and cost-effective procedure to separate bovine milk-derived extracellular vesicles via salting-out and aimed to profile their proteomics as one important characterization in EV research.
ORGANISM(S): Bos taurus (Bovine) 
2021-11-02 | PXD028095 | Pride
Lc-msms Extracellular vesicles Bovine Milk 
UnknownModular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure.

Background

Analyzing disease-disease relationships plays an important role for understanding etiology, disease classification, and drug repositioning. However, as cardiovascular diseases with causative links, the molecular relationship among stable angina pectoris (SAP), ischemic cardiomyopa...
S-EPMC9701405 | biostudies-literature
UnknownThe influence of postharvest UV-C treatment on anthocyanin biosynthesis in fresh-cut red cabbage.
Red cabbage (Brassica oleracea L. var. capitata f. rubra DC.) is a fresh edible vegetable consumed globally that contains high levels of antioxidant compounds including anthocyanins. In this study, fresh-cut red cabbage was treated with different Ultraviolet-C (UV-C) dosages. Fifteen cyanidin deriva...
S-EPMC5507880 | biostudies-literature
UnknownIcariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway.
Background: Endothelial dysfunction is commonly accompanied by a reduced capacity for nitric oxide (NO) production and decreased NO sensitivity, playing a central role in numerous vascular diseases. Saturated free fatty acids are known to reduce NO production and then induce endothelial dysfu...
S-EPMC9280058 | biostudies-literature
UnknownTranscriptome analysis highlights the role of ferroptosis in palmitic acid-induced endothelial dysfunction.

Background

Palmitic acid (PA) has a lipotoxic effect on blood vessels, leading to endothelial dysfunction and cell death. The underlying mechanisms are not yet fully understood.

Aim

We sought to investigate the effects of PA on endothelial cells, with an emphasis on ferroptosis.

Me...

S-EPMC10089063 | biostudies-literature
UnknownLow-Molecular-Weight Heparin-Functionalized Chitosan-Chondroitin Sulfate Hydrogels for Controlled Release of TGF-β3 and in vitro Neocartilage Formation.
Repair of hyaline cartilage remains a huge challenge in clinic because of the avascular and aneural characteristics and the paucity of endogenous repair cells. Recently, tissue engineering technique, possessing unique capacity of repairing large tissue defects, avoiding donor complications and two-s...
S-EPMC6839338 | biostudies-literature
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