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ProteomicsOLFM4 expression in breast tumor samples
Here we describe the first study which used SWATH MS as a tool for robust identification and quantification of breast tissus proteins. By employing a spectral library containing 3200 proteins, we show that this strategy allows the quantification of OLFM4 in each sample together with a deep proteomic...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD014194 | Pride
Breat cancer Swath-ms Olfm4 
ProteomicsLong-Chain Acyl Coenzyme A Dehydrogenase, a Key Player in Metabolic Rewiring/Invasiveness in Experimental Tumors and Human Mesothelioma Cell Lines
Cross-species investigations of cancer invasiveness are a new approach that has already identified new biomarkers which are potentially useful for improving tumor diagnosis and prognosis in clinical medicine and veterinary science. In this study, we combined proteomic analysis of four experimental r...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-06-20 | PXD042942 | Pride
Malignant mesothelioma  metabolism  mitochondria  long-chain specific acyl-coa dehydrogenase  fatty acid β-oxidation  biomarker 
ProteomicstRNA Biogenesis and Specific Aminoacyl-tRNA Synthetases Regulate Senescence Stability Under the Control of mTOR
Oncogenes or chemotherapy treatments trigger the induction of suppressive pathways such as apoptosis or senescence. Senescence was initially defined as a definitive arrest of cell proliferation but recent results have shown that this mechanism is also associated with cancer progression and chemother...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD029535 | Pride
Chemotherapy Trna Er stress Senescence P21 Mtor 
ProteomicsProteomics of tumor and serum samples from isocitrate dehydrogenase-wildtype glioblastoma patients: is the detoxification of reactive oxygen species associated with shorter survival?
Proteomics has been little used for the identification of novel prognostic and/or therapeutic markers in isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GB). In this study, we analyzed 50 tumor and 30 serum samples from short- and long-term survivors of IDH-wildtype GB (STS and LTS, respective...
ORGANISM(S): Homo sapiens (Human) 
2024-07-04 | PXD045714 | Pride
Dia-ms  tims-tof-pro  glioblastoma  survival 
ProteomicsAnterior Gradient protein 2 is a marker of tumor aggressiveness in breast cancer and favors chemotherapy-induced senescence escape.
Among the different chemotherapies available, genotoxic drugs are widely used. In response to these drugs, particularly doxorubicin, tumor cells can enter into senescence. Chemotherapy-induced senescence (CIS) is a complex response. Long described as a definitive arrest of cell proliferation, we and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028073 | Pride
Chemotherapy Agr2 Senescence 
TranscriptomicsGene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response
Triple-negative (TN) breast cancers need to be refined in order to identify therapeutic subgroups of patients. We conducted an unsupervised analysis of microarray gene-expression profiles of 107 TN breast cancer patients and undertook robust functional annotation of the molecular entities found by ...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-58812 | biostudies-arrayexpress
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