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MetabolomicsAn LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

INTRODUCTION: Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress. Hydrogen gas (H2) ...

2021-10-06 | MTBLS2418 | MetaboLights
ProteomicsQuantitative Proteomics of Cochlear Tissues: Bilateral Comparisons in Guinea Pigs and Rats
The cochlea, a sensitive biosensor, detects sound waves and converts them into electrical signals the brain recognizes as sound. Damage to cochlear hair cells can release proteins, triggering biological responses that may impair hearing. Mass spectrometry-based proteomics offers insights into protei...
ORGANISM(S): Cavia porcellus (Guinea pig) Rattus norvegicus (Rat) 
2025-07-21 | PXD059025 | Pride
Mass-spectrometry Cochlear tissue Rat Proteomics Guinea pigs 
ProteomicsProteomic study of the retina of guinea pigs with form-deprivation myopia
Myopia has become the major cause of visual impairment worldwide. However, its retina-related pathogenesis remains unclear. In recent years, proteomics has become a high-throughput tool to explain biological mechanisms. In this study, we examined the retinas of guinea pigs with form deprivation myop...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2023-07-12 | PXD043226 | Pride
Guinea pig Proteome Retina 
TranscriptomicsDevelopment of oligonucleotide microarray to study global gene expression profile in guinea pigs in response to tuberculosis infection
In this study we developed a guinea pig oligonucleotide microarray (GPOM) comprising of a total number of 45,220 features including 43,803 valid features from different mammalian species. These features are inclusive of 2971 newly annotated probes corresponding to 344 unique genes of guinea pig. As ...
ORGANISM(S): Cavia porcellus 
2012-10-01 | E-GEOD-32447 | biostudies-arrayexpress
ProteomicsWidespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs
Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine acetylation of proteins plays a key role in regu...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2023-07-12 | PXD043196 | Pride
Form-deprivation myopia  retina  lysine acetylation  glycolysis 
ProteomicsCavia porcellus spectral library
The guinea pig (cavia porcellus) is an excellent experimental model for translation to many aspects of human physiology and disease yet there is limited experimental information regarding its proteome. In an effort to overcome this gap in our knowledge, we generated a comprehensive spectral library ...
ORGANISM(S): Cavia Porcellus (ncbitaxon:10141) 
2018-12-07 | MSV000083199 | MassIVE
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. The retinal–choroid–sclera (RCS) signalling cascade is crucial in regulating eye growth and is influenced by visually induced signalling. Understanding the molecular mechanisms underlying this cascade is vital to identify therapeutic targets for myop...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD052167 | Pride
Phosphoproteomic Proteomic Form-deprivation myopia (fdm)  retina-choroid-sclera (rcs) 
ProteomicsProteomics analysis of guinea pig retina at the early stage of myopia
This is a combined SWATH database of early myopic guinea pig retina. The retinal tissues were divided into lens induced myopia 4 days group (4-day LIM) and control group; 5 individual animals (10 retinas) were included. The potential biomarkers and underlying biochemical pathways during early myopia...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2021-05-13 | PXD025003 | Pride
Proteomics guinea pig retina myopia 
TranscriptomicsGene expression pattern after insertion of dexamethasone-eluting electrode into the guinea pig cochlea.
To investigate the effect of the dexamethasone-eluting electrode in the guinea pig cochlea, and compared the gene expression after 7 days insertion with that of a normal electrode or non-treated control by microarray. Male Hartley guinea pigs (SLC, Shizuoka, Japan) with an age of seven weeks were us...
ORGANISM(S): Cavia porcellus 
2014-01-17 | E-GEOD-53866 | biostudies-arrayexpress
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067757 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
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