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ProteomicsThe proteome of normal human sclera
The optic nerve is a white matter tract that conveys visual information to the brain. The sclera comprises the white, protective outer layer of the eye. A characterization of the proteome of normal human retrobulbar optic nerve and sclera may facilitate studies of the eye. We conducted a proteomic a...
ORGANISM(S): Homo sapiens (Human) 
2020-11-24 | PXD022661 | Pride
Human Sclera Proteome 
ProteomicsThe proteome of normal human sclera
The sclera provides an opaque protective coat for five-sixths of the surface of the human eye. A detailed investigation of the proteome of the normal human sclera may provide insights into the biology and pathophysiology of the sclera. We conducted an in-depth proteomic analysis of sclera from five ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD004223 | Pride
Collagen Proteome Myopia Sclera Eye / human 
ProteomicsMouse cornea,sclera,skin LC-MSMS
We generated a P4ha2 knock-out mouse line (C57BL/6) by using CRISPR-Cas9 system. By mass spectrum, reduced proline hydroxylation was observed in collagens isolated from skin, sclera and cornea of P4ha2-/- mice.
ORGANISM(S): Mus musculus (Mouse) 
2026-03-02 | PXD023006 | Pride
Skin lc-msms Mouse cornea Sclera 
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067756 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
TranscriptomicsGene expression profiling of mouse sclera during post-natal development
Although there have been studies conducted on cornea and retina growth and development, postnatal gene expression studies on sclera growth during postnatal growth has not been well characterised. Given that the mouse genome has 85% homology to the human genome and has been completely sequenced, mous...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28056 | biostudies-arrayexpress
ProteomicsProteomic analysis of human sclera tissue using high resolution mass spectrometry
The sclera is white, tough outer covering, known for providing structural support to the eyeball and the intraocular contents. Any abnormality in sclera results in disorders such as conjunctivitis, episcleritis, scleritis and hence a proper investigation will help in preventing the same. In the curr...
ORGANISM(S): Homo sapiens (Human) 
2019-02-21 | PXD008999 | Pride
Protein profiling Omics technology Tandem mass spectrometry Protein abundance Eye proteome 
TranscriptomicsHuman sclera
The sclera maintains and protects the eye ball, which receives visual inputs. The aim of this study is to identify characteristics of the human sclera as one of the connective tissues derived from the neural crest and mesoderm. We have here demonstrated microarray data of cultured human scleral cell...
ORGANISM(S): Homo sapiens 
2008-04-10 | GSE10934 | GEO
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. The retinal–choroid–sclera (RCS) signalling cascade is crucial in regulating eye growth and is influenced by visually induced signalling. Understanding the molecular mechanisms underlying this cascade is vital to identify therapeutic targets for myop...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD052167 | Pride
Phosphoproteomic Proteomic Form-deprivation myopia (fdm)  retina-choroid-sclera (rcs) 
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067757 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067446 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
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