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ProteomicsLabel-free proteome analysis of small extracellular vesicles (sEV) expressing different HRS mutants.
Label-free proteome analysis of small extracellular vesicles (sEV) derived from WM9 cells expressing different HRS mutants: wild type (HRSWT), phospho-deficient (HRSS345A), and phospho-mimetic mutant HRS (HRSS345D).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-16 | MSV000088846 | MassIVE
MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
UnknownGenome of the estuarine oyster provides insights into climate impact and adaptive plasticity.
Not available
S-EPMC8590024 | biostudies-literature
ProteomicsIn-depth Mass Spectrometry Analysis Reveals the Plasma Proteomic and N-glycoproteomic Impact of an Amish Enriched Cardioprotective Variant in B4GALT1
Proteome and N-glycoproteome in human plasma were analyzed and compared between B4GALT1 WT and N352S genotypes. The results showed that N352S significantly decreased galactosylation for a wide range of proteins, especially apoB and fibrinogen, which may be associated with the decreased LDL-c level o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-29 | MSV000090976 | MassIVE
ProteomicsThe essential role of stress granules in cGAS sensing of DNA
cGAS-associated cellular proteins through performing co-immunoprecipitation (co-IP) followed by mass spectrometry and proteomic analysis
ORGANISM(S): Homo Sapiens 
2019-02-24 | PXD012847 |
ProteomicsNovel Peptidomic Analysis Identifies Peptide Clusters with Potential for Disease Diagnosis and Dysregulated Proteolytic Processing
Mass spectrometry-based peptidomics provides a comprehensive approach to delineate the global proteolytic landscape of diseases and to identify potential biomarkers. However, current data analysis methods struggle to distill the peptidomic signatures of diseases. In this study, we conducted a peptid...
ORGANISM(S): Homo Sapiens 
2025-04-02 | PXD062496 |
ProteomicsA global multi-regional proteomic map of the human cerebral cortex
In this study, four groups of the iTRAQ quantification experiment using 2D-LC-MS/MS analysis, one group of the label-free quantification experiment using 2D-LC-MS/MS analysis, one group of the PRM quantification experiment of the human brain tissue were included. Therefore, six subprojects are incl...
ORGANISM(S): Homo Sapiens 
2021-03-09 | PXD024613 |
ProteomicsPlasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducte...
ORGANISM(S): Homo Sapiens 
2022-03-10 | PXD032179 |
ProteomicsProteomic analysis of 442 clinical plasma samples from healthy donors and COVID-19 covalescent patients
In this study, we collected plasma samples from 22 healthy controls (HC group), 43 hospitalized patients (HO group), 196 convalescent patients 6 months after COVID-19 infection (first follow-up, F1 group), and 181 convalescent patients 12 months after COVID-19 infection (second follow-up, F2 group)....
ORGANISM(S): Homo Sapiens 
2024-08-02 | PXD054533 |
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