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ProteomicsPhosphoproteomics analysis of TAMs with NEK2 overexpression
NEK2 is considered a key factor in the maintenance of development and function of B cells in multiple myeloma (MM). Importantly, we previously demonstrated that PD-L1 is a substrate of NEK2, and combinatorial inhibition of NEK2 and PD-L1 largely improves the therapeutic efficacy of pancreatic cancer...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD054708 | Pride
Nek2  phosphoproteomics tams  pancreatic cancer 
ProteomicsLC-MS proteomics quantitative analysis of pancreatic cancer cells overexpressing NEK2
The NEK2 overexpression in pancreactic cancer cell (SW1990), and we performed LC-MS to further investigate the manner in which NEK2 regulates PD-L1.
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD026877 | Pride
Human Pancreatic cancer cell Lc-ms 
ProteomicsZebrafish Study Provides Evidence for Porphyromonas gingivalis Outer Membrane Vesicles Eliciting Alzheimer's Disease-Like Pathologies
Periodontitis bacteria release vesicles that can harm the brain. In zebrafish, these vesicles caused brain injury, inflammation, movement problems, and Alzheimer’s-like changes, including amyloid plaques and enzyme activity. This study suggests periodontitis may contribute to Alzheimer’s disease.
ORGANISM(S): Danio Rerio 
PXD067862 |
ProteomicsAmelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
Nonalcoholic fatty liver disease (NAFLD) including its more severe manifestation, nonalcoholic steatohepatitis (NASH), is a global public health challenge. Here, we reveal a role for the deubiquitinating enzyme RPN11 in the development of NAFLD and NASH. Ablation of hepatic RPN11 markedly protected ...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD053163 |
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