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ProteomicsCell cycle dependent NEK2 interactome
TurboID proximity labeling was used to evaluate cell cycle dependent NEK2 interactome
ORGANISM(S): Homo sapiens (Human) 
2026-01-28 | PXD068515 | Pride
Nek2  interactome  cell cycle 
ProteomicsLC-MS proteomics quantitative analysis of pancreatic cancer cells overexpressing NEK2
The NEK2 overexpression in pancreactic cancer cell (SW1990), and we performed LC-MS to further investigate the manner in which NEK2 regulates PD-L1.
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD026877 | Pride
Human Pancreatic cancer cell Lc-ms 
GenomicsNEK2 regulates triple negative breast cancer transcriptome.
NEK2 regulates triple negative breast cancer transcriptome.
PRJNA590988 | ENA
ProteomicsPhosphoproteomics analysis of TAMs with NEK2 overexpression
NEK2 is considered a key factor in the maintenance of development and function of B cells in multiple myeloma (MM). Importantly, we previously demonstrated that PD-L1 is a substrate of NEK2, and combinatorial inhibition of NEK2 and PD-L1 largely improves the therapeutic efficacy of pancreatic cancer...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD054708 | Pride
Nek2  phosphoproteomics tams  pancreatic cancer 
TranscriptomicsNEK2 regulates triple negative breast cancer transcriptome.
NEK2 is a mitotic kinase that is upregulated and mislocalized in the nucleus of human cancer cells. NEK2 modulates expression and activity of both transcription and splicing factors in cancer cells, nevertheless whether this kinase affects transcriptome regulation genome widely and whether this acti...
ORGANISM(S): Homo sapiens 
2021-12-21 | GSE140803 | GEO
GenomicsEffect of NEK2 deficiency on gene expression of CD19-selected spleen B cells of Eμ-myc mouse model
Effect of NEK2 deficiency on gene expression of CD19-selected spleen B cells of Eμ-myc mouse model
PRJNA941214 | ENA
GenomicsTargeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer
PRJNA624895 | ENA
TranscriptomicsEffect of NEK2 deficiency on gene expression of CD19-selected spleen B cells of Eμ-myc mouse model
NEK2 overexpression in the B cell lineage affects B cell development. To determine whether deficiency of NEK2 inhibits B cell malignancies, we crossed Nek2 knockout mice with Eμ-myc transgenic mice, a well-established Myc-driven preclinical model for B cell malignancies. Three genotyping offsprings ...
ORGANISM(S): Mus musculus 
2023-06-01 | GSE226675 | GEO
GenomicsTargeting the mitotic kinase NEK2 improves the efficacy of CDK4/6 inhibitors
Targeting the mitotic kinase NEK2 improves the efficacy of CDK4/6 inhibitors
PRJNA1160795 | ENA
TranscriptomicsTargeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer
We report that NEK2 protein level is overexpressed and correlated with the tumor stage and lymph node metastasis in cervical cancer. Furthermore, we provided evidence that NEK2-depleted cervical cancer cells exhibit impaired oncogenesis and enhanced radiosensitivity. Using RNA sequencing, we identif...
ORGANISM(S): Homo sapiens 
2021-04-30 | GSE148531 | GEO
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