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TranscriptomicsGene expression profiles of tumor-associated macrophages (TAMs) overexpressing miR-511-3p
Hematopoietic stem/progenitor cells (HS/PCs) were transduced with lentiviral vectors overexpressing OFP and either miR-511-3p or a control, mutated miRNA sequence (miR-511-3p-mut). The transduced HS/PCs were then transplanted in recipient C57BL/6 mice. Tumors (Lewis lung carcinomas, LLC) were inject...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-34903 | biostudies-arrayexpress
GenomicsTranscriptome sequencing analysis of CSF-1Rhigh TAMs and CSF-1Rlow TAMs in colon adenocarcinoma.
Transcriptome sequencing analysis of CSF-1Rhigh TAMs and CSF-1Rlow TAMs in colon adenocarcinoma.
PRJNA798035 | ENA
ProteomicsPhosphoproteomics analysis of TAMs with NEK2 overexpression
NEK2 is considered a key factor in the maintenance of development and function of B cells in multiple myeloma (MM). Importantly, we previously demonstrated that PD-L1 is a substrate of NEK2, and combinatorial inhibition of NEK2 and PD-L1 largely improves the therapeutic efficacy of pancreatic cancer...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD054708 | Pride
Nek2  phosphoproteomics tams  pancreatic cancer 
TranscriptomicsComparison of Invasive TAM sub-population to General TAM population
The tumor microenvironment modifies the malignancy of tumors. In solid tumors this environment is populated by many macrophages (tumor-associated macrophages; TAMs) that in genetic studies that depleted these cells from mouse models of breast cancer were shown to promote tumor progression to maligna...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-18295 | biostudies-arrayexpress
TranscriptomicsHigh-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors
Clinical and experimental evidence indicates that tumor-associated macrophages (TAMs) promote malignant progression. In breast cancer, TAMs enhance tumor angiogenesis, tumor cell invasion, matrix remodeling, and immune suppression against the tumor. In this study, we examined late-stage mammary tumo...
ORGANISM(S): Mus musculus 
2010-06-21 | E-GEOD-18404 | biostudies-arrayexpress
ProteomicsProteomic profiling of oleamide-mediated polarization in a primary human monocyte-derived tumor-associated macrophages model: a functional analysis
To investigate the effect of oleamide on tumor-associated macrophages (TAMs) polarization.
ORGANISM(S): Homo sapiens (Human) 
2024-08-25 | PXD043461 | Pride
Oleamide Tumor-associated macrophages Polarization Proteomic Tam 
GenomicsApolipoprotein A1-Manipulated Cholesterol Efflux Subverts the Phagocytic Fragility of TAMs and Improves Oncolytic Viro-Immunotherapy in Glioblastoma [TAMs RNA-seq]
Apolipoprotein A1-Manipulated Cholesterol Efflux Subverts the Phagocytic Fragility of TAMs and Improves Oncolytic Viro-Immunotherapy in Glioblastoma [TAMs RNA-seq]
PRJNA833881 | ENA
GenomicsMurine macrophages: Peritoneal exudate macrophages (PECs) vs tumor-associated macrophages (TAMs)
Murine macrophages: Peritoneal exudate macrophages (PECs) vs tumor-associated macrophages (TAMs)
PRJNA704618 | ENA
GenomicsTumor-associated macrophages (TAMs) with or without HRS knockdown (KD)
Tumor-associated macrophages (TAMs) with or without HRS knockdown (KD)
PRJNA1291646 | ENA
ProteomicsBTN2A1 Targeting Reprograms M2-like Macrophages and TAMs via SYK and MAPK Signaling
Tumor-associated macrophages (TAMs), often adopting an immunosuppressive M2-like phenotype, correlate with unfavorable cancer outcomes. Our investigation unveiled elevated expression of the butyrophilin (BTN)2A1 in M2-like TAMs across diverse cancer types. We developed anti-BTN2A1 monoclonal antibod...
ORGANISM(S): Homo sapiens (Human) 
2024-09-02 | PXD055262 | Pride
Lc-msms Ap-ms Butyrophilin (btn)2a1 Reprogramming Mapk Immunosuppressive m2-like Syk Cancer 
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