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MetabolomicsA microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions

The blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity. We developed a physiologically relevant human neurovascular unit microfluidic chip (hNVU-on-a-chip) incorporating brain microvascular endoth...

2025-10-28 | MTBLS13230 | MetaboLights
MetabolomicsEffects of synbiotic formulations on the pig gut microbiome

We assessed the ability of three synbiotic formulations to improve gut health by stabilizing the gut microbiome and to prevent post-weaning diarrhoea in vivo in piglets using a mild Escherichia coli infection model.

2026-04-14 | MTBLS13996 | MetaboLights
MetabolomicsCalenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in a type 2 diabetes model Calenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in cell, organ-on-a-chip, and mouse models of type 2 diabetes.

Glibenclamide (GLIB), a type 2 diabetes therapy, has long-term safety concerns. Probiotic–drug coadministration, an emerging adjunctive approach for metabolic diseases, improves therapeutic outcomes and side effects. Here, Bifidobacterium animalis B960 was selected from 71 probiotic strains by HP...

2025-07-08 | MTBLS12697 | MetaboLights
ModelsLee2017 - Paracetamol first-pass metabolism PK model
Authors developed a microfluidic gut-liver co-culture chip that aims to reproduce the first-pass metabolism of oral drugs. The study suggests the possibility of reproducing the human PK profile on a chip, contributing to accurate prediction of pharmacological effect of drugs.
2024-09-02 | BIOMD0000000947 | BioModels
ProteomicsBacterial outer membrane protein prevents enteric Salmonella infection
Probiotics have become promising strategies for treating intestinal barrier dysfunction. However, the mechanisms by which probiotic bacteria interact with host cells to elicit beneficial effects remain unclear. Herein, we demonstrate that administration of E. coli Nissle 1917 (EcN) before Salmonella...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. STm1 Homo sapiens (Human) Escherichia coli 
2026-03-10 | PXD068469 | Pride
Host-microbe interaction Salmonella typhimurium Probiotics Gut-on chip E. coli nissle 1917 
UnknownDeveloping an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions.
Not available
S-EPMC9930731 | biostudies-literature
TranscriptomicsGlycan effect on Saccharolytic Human Distal Gut Symbiont, B. thetaiotaomicron
This SuperSeries is composed of the following subset Series: GSE11944: Mucosal Glycan Foraging Enhances the Fitness and Transmission of a Saccharolytic Human Distal Gut Symbiont GSE11953: Mucosal Glycan Foraging Enhances the Fitness and Transmission of a Saccharolytic Human Distal Gut Symbiont: ECF ...
ORGANISM(S): Bacteroides thetaiotaomicron 
2008-11-20 | E-GEOD-11980 | biostudies-arrayexpress
TranscriptomicsEffects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: a Randomized Double-blind Placebo-controlled Trial
The gut microbiota has been implicated in obesity and cardiometabolic diseases, although evidence in humans is scarce. We investigated how gut microbiota manipulation by antibiotics (7-day administration of amoxicillin, vancomycin, or placebo) affects host metabolism in 57 obese, prediabetic men. Va...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-76003 | biostudies-arrayexpress
ProteomicsInvestigating the impact of SopB on the gut epithelium – proteome and phosphoproteome
In this study, the impact of the Salmonella SPI1 effector SopB on the gut epithelium was investigated based on a proteome and a phosphoproteome.
ORGANISM(S): Mus musculus (Mouse) 
2026-07-07 | PXD046081 | Pride
Salmonella Phosphoproteome Sopb Mice Lfq M-iccl2 Proteome 
TranscriptomicsA modular-designed millifluidic organ-on-a-chip device to recapitulate key human gut epithelium features in the perspective of microbiota-gut-brain axis
The ERC “MINERVA” project (GA 724734) aims at developing a multi-organ-on-a-chip engineered platform to recapitulate in vitro the main players involved in the MGBA crosstalk: the microbiota, the gut epithelium, the immune system, the blood-brain barrier and the brain. In this context, the gut epithe...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-11949 | biostudies-arrayexpress
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