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MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
MetabolomicsHelicobacter pylori infection promotes TMAO accumulation through Escherichia coli enrichment with gut–liver circadian disruption and hepatic metabolic injury
Helicobacter pylori (H. pylori) infection is associated with metabolic dysfunction-associated steatotic liver disease, but the microbial changes and circadian disturbances accompanying distal hepatic injury remain unclear. In specific pathogen-free (SPF) mice exposed to dietary choline, H. pylori in...
2026-09-18 | MTBLS15673 | MetaboLights
MetabolomicsUntargeted LC-MS/MS metabolomic profiling of Helicobacter pylori-infected gastric epithelial cells treated with Latilactobacillus sakei
This study employed untargeted LC-MS/MS metabolomics to investigate the effects of Latilactobacillus sakei on metabolic alterations in Helicobacter pylori-infected gastric epithelial cells. Metabolomic analysis revealed that Latilactobacillus sakei intervention modulated host cellular metabolism, pa...
2026-10-09 | MTBLS15966 | MetaboLights
TranscriptomicsHelicobacter pylori pathogenic mechanism
Helicobacter pylori infection reprograms host gene expression and influences various cellular processes, which have been investigated by cDNA microarray in vitro culture cells and in vivo patients of the chronic abdominal complaint. In this study，the effects of H. pylori infection on host gene expre...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-30042 | biostudies-arrayexpress
TranscriptomicsBifidobacterium bifidum BF-1 Suppresses Helicobacter pylori-Induced genes in Human Epithelial Cells
We have shown that pre-incubation with Bifidobacterium bifidum (B. bifidum) strain BF-1, a probiotic strain known to improve H. pylori-associated gastritis, suppresses the induction of IL-8 by the pathogen. To investigate how BF-1 affects gene expression in H. pylori-infected cells, we performed m...
ORGANISM(S): Homo sapiens 
2010-10-13 | E-GEOD-20171 | biostudies-arrayexpress
ProteomicsComparative proteomics of Helicobacter pylori strains reveals geographical features rather than genomic variations
Helicobacter pylori, which is known as pathogens of various gastric diseases, have many types of genome sequence variants. That is part of the reason why pathogenesis and infection mechanisms of the H. pylori-driven gastric diseases have not been well clarified yet. Here we performed a large-scale p...
ORGANISM(S): Helicobacter Pylori F16 Helicobacter Pylori F30 Helicobacter Pylori Helicobacter Pylori Ok113 Helicobacter Pylori Ok310 Helicobacter Pylori F32 
2018-12-28 | PXD011364 | JPOST Repository
TranscriptomicsPolarized T84 Cells Response to H. pylori infection
All arrays use the same reference, which is cDNA generated from RNA harvested from uninfected polarized T84 monolayers. Infections were done on two seperate days. Numbers following the name of each array designate the time point post H. pylori infection. Data for time course one is named such tha...
ORGANISM(S): Homo sapiens 
2006-01-10 | E-GEOD-4012 | biostudies-arrayexpress
Proteomicshuman H. pylori induced TAK1/TAB1 interactomics
Study of dynamic changes in TAK1/TAB1 complex formation after H. pylori infection in human epithelial cells
ORGANISM(S): Homo sapiens (Human) 
2017-12-06 | PXD007632 | Pride
Tab1 H. pylori infection Interactomics Tak1 Human Epithelial cells 
TranscriptomicsH. pylori strain comparisons
Helicobacter pylori enhances the risk for ulcer disease and gastric cancer, yet only a minority of H. pylori-colonized individuals develop disease. We examined the ability of two H. pylori isolates to induce differential host responses in vivo or in vitro, and then used an H. pylori whole genome mic...
ORGANISM(S): Helicobacter pylori 
2005-08-16 | E-GEOD-3135 | biostudies-arrayexpress
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