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TranscriptomicsIdentification of novel metastases-suppressor genes involved in lung cancer brain metastases formation.
Initial screening for potential metastases suppressors down regulated by methylation was performed using lung cancer cell line models specific for site-specific metastasation. Gene expression profiling and qRT-PCR validations were conducted on tumor tissues from primary lung cancer (LC) and brain me...
ORGANISM(S): Homo sapiens 
2014-11-18 | E-GEOD-57492 | biostudies-arrayexpress
GenomicsGenome-wide identification of PPARG binding sites in NCI-H2347 and NCI-H1993 cell lines
While the regulation of metabolic enzymes by oncogenic drivers or tumor suppressors has been intensively studied over recent years, our understanding of how metabolic processes directly regulate cell proliferation has remained fragmentary. Here we show how the alteration of metabolism directly affec...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-58382 | biostudies-arrayexpress
TranscriptomicsMicrotubule Affinity-Regulating Kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.
MARK2 expression is associated with the malignant phenotype, expression of DNA repair components, NF-κB inhibition and cell cycle transcription factors in lung cancer cells We used microarrays to determine the global gene expression pattern associated with knockdown of MARK2 3 lung cancer cell lines...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-57966 | biostudies-arrayexpress
ProteomicsVariability in exosomal protein cargo of human lung adenocarcinoma cells
Exosomal protein cargo has been shown to have a significant implication in lung cancer research. Our study deals with three lung cancer cell line exosomes. The purpose of this project is to analyze the qualitative and quantitative variability in replicates (TRs and Brs). We performed various statist...
ORGANISM(S): Homo sapiens (Human) 
2020-03-04 | PXD012798 | Pride
H1975 cell line Technical replicates (trs) A549 cell line Quantitative data H1993 cell line Biological replicates (brs) Qualitative data 
UnknownCheckpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer.
Not available
S-EPMC4073630 | biostudies-literature
TranscriptomicsTranscriptomic analysis of TDRD9-depleted lung tumor cells
Tudor domain containing protein 9 (TDRD9) is a RNA helicase normally expressed in the germline. We have shown that TDRD9 is highly expressed in a subset of non-small cell lung carcinomas. Here we determine the transcriptomic changes of a TDRD9-positive lung tumor cells line (NCI-H1993) depleted of T...
ORGANISM(S): Homo sapiens 
2018-09-23 | GSE104151 | GEO
UnknownSignatures of drug sensitivity in nonsmall cell lung cancer.
Not available
S-EPMC3200133 | biostudies-literature
UnknownQuantitative Secretomic Analysis Identifies Extracellular Protein Factors That Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer.
Not available
S-EPMC5001500 | biostudies-literature
TranscriptomicsQuinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, Nuclear Factor-kappa B and Cell Cycle Progression in Non-Small Cell Lung Cancer
Erlotinib is a tyrosine kinase inhibitor (TKI) that is approved as a second-line monotherapy in patients with advanced non-small cell lung cancer (NSCLC). In these patients, erlotinib prolongs survival but its benefit remains modest since many tumors express wild-type EGF receptor (wtEGFR) lacking a...
ORGANISM(S): Homo sapiens 
2014-06-19 | GSE57422 | GEO
TranscriptomicsNSCLC_cellLine_expression
Deoxyazacitidine is used to elicit expression of cancer specific methylated genes. Non-small cell lung cancer cell lines are treated with either deoxyazacitidine or trichostatin A to identify cancer specific methylation
ORGANISM(S): Homo sapiens 
2013-12-10 | E-MTAB-1939 | biostudies-arrayexpress
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