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MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
TranscriptomicsA Basic Domain in the Histone H2B N-terminal Tail is Important for Nucleosome Assembly by FACT
Nucleosome assembly in vivo requires assembly factors, such as histone chaperones, to bind to histones and mediate their deposition onto DNA. In yeast, the essential histone chaperone FACT (FAcilitates Chromatin Transcription) functions in nucleosome assembly and H2A-H2B deposition during transcript...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-10 | E-GEOD-80831 | biostudies-arrayexpress
GenomicsGlcNAcylation of histone H2B facilitates its monoubiquitination [Illumina Genome Analyzer data]
We report that histone GlcNAcylation of H2B S112 is a vital histone modification which facilitates histone monoubiquitination (ub). In a genome-wide analysis, H2B S112 GlcNAcylation sites were observed widely distributed over entire chromosomes including transcribed gene loci, together with co-local...
ORGANISM(S): Homo sapiens 
2011-10-27 | E-GEOD-33049 | biostudies-arrayexpress
TranscriptomicsHistone H2B K111A
Total RNA from three replicate cultures of wild-type and mutant strains was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by histone H2B K111A mutant. Comparison of genes whose mRNA leve...
ORGANISM(S): Saccharomyces cerevisiae 
2010-03-09 | E-GEOD-15203 | biostudies-arrayexpress
TranscriptomicsHistone H2B R102A
Total RNA from three replicate cultures of wild-type and mutant strains was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by histone H2B R102A mutant. Comparison of genes whose mRNA leve...
ORGANISM(S): Saccharomyces cerevisiae 
2010-03-09 | E-GEOD-15202 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae where Histone H2B was mutated to give H2B^3-37 to identify genes regulated by the H2B N-terminal domain
Histone H2B was mutated to give H2B^3-37. Total RNA from three replicate cultures of wild-type and mutant was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by H2B N-terminal domain. Ex...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3804 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae histone H2Bdelat30-37 mutants vs wild type to determine the role of H2B N terminal domaon in transcription
Histone H2B was mutated to give H2B^30-37. Total RNA from three replicate cultures of wild-type and mutant was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by H2B HBR domain. Experime...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3805 | biostudies-arrayexpress
GenomicsCo-dependency of H2B monoubiquitination and nucleosome re-assembly on Chd1
Monoubiquitination of histone H2B on lysine 123  (H2BK123ub) is a transient histone modification considered to be essential for establishing H3K4 and H3K79 trimethylation by Set1/COMPASS and Dot1, respectively.  Many of the factors such as Rad6/Bre1, the Paf1 complex, and the Bur1/Bur2 complex were ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-01 | E-GEOD-36334 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae H2B K6,11,16,17,21,22G mutant vs. wild type to investigate the role of H2B N-terminal domain in transcription
Histone H2B was mutated to give H2B K6,11,16,17,21,22G. Total RNA from three replicate cultures of wild-type and mutant was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by H2B N-termi...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3803 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae H2B^3-32 mutants to investigate the role of hstone H2B N-terminal domain in genome wide transcription
Histone H2B was mutated to give H2B^3-32. Total RNA from three replicate cultures of wild-type and mutant was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by H2B N-terminal domain. Ex...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3802 | biostudies-arrayexpress
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