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UnknownStructural insights into the recognition of histone H3Q5 serotonylation by WDR5.
Not available
S-EPMC8213231 | biostudies-literature
ProteomicsHistone peptide pull-down H3K4me0-3 +/- H3Q5ser
The interactome to H3 peptides in different H3K4 methylation states and its change upon H3Q5 serotonylation was determined by performing peptide pull-down followed by qMS. Streptaviding beads, saturated with biotinylated H3 peptides in all possible H3K4 methylation states and with presence and absen...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD062109 | Pride
Hela H3 H3q5 
GenomicsMAOA+ CAFs enforce immune exclusion in pancreatic cancer by restraining serotonin-dependent histone H3Q5 serotonylation
MAOA+ CAFs enforce immune exclusion in pancreatic cancer by restraining serotonin-dependent histone H3Q5 serotonylation
PRJNA1504281 | ENA
UnknownHistone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout.
Not available
S-EPMC8017887 | biostudies-literature
TranscriptomicsHistone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity
Histone H3 monoaminylations at glutamine(Q) 5 represent important epigenetic markers in neurons that play critical roles in the mediation of permissive gene expression. We previously demonstrated that H3Q5 serotonylation(ser) and dopaminylation(dop) are catalyzed by the Transglutaminase 2 (TGM2) enz...
ORGANISM(S): Mus musculus 
2022-12-06 | GSE209834 | GEO
ProteomicsHistone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity
Histone H3 monoaminylations at glutamine(Q) 5 represent an important family of epigenetic markers in neurons that play critical roles in the mediation of permissive gene expression (1, 2). We previously demonstrated that H3Q5 serotonylation(ser) and dopaminylation(dop) are catalyzed by the Transglut...
ORGANISM(S): Homo sapiens (Human) 
2024-10-10 | PXD053429 | Pride
Tgm2 Serotonylation Neural rhythmicity Histone h3 
ProteomicsHistone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity
Histone H3 monoaminylations at glutamine(Q) 5 represent an important family of epigenetic markers in neurons that play critical roles in the mediation of permissive gene expression (1, 2). We previously demonstrated that H3Q5 serotonylation(ser) and dopaminylation(dop) are catalyzed by the Transglut...
ORGANISM(S): Homo sapiens (Human) 
2024-10-10 | PXD053788 | Pride
Tgm2 Bidirectionally controls h3 monoaminylation dynamics Which Facilitate neural rhythmicity. In turn A single enzyme 
GenomicsTGM2-Mediated Histone Transglutamination is Dictated by Steric Accessibility
Histone monoaminylation is a new class of chromatin post-translational modification whereby glutamines are transamidated by tissue transglutaminase 2 (TGM2). Initial studies of these marks have identified serotonylation and dopaminylation on H3Q5, suggesting the modification is a marker of active ch...
ORGANISM(S): Homo sapiens 
2022-10-05 | GSE198978 | GEO
UnknownRegioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation.
Not available
S-EPMC12282475 | biostudies-literature
TranscriptomicsMAOA+ CAFs enforce immune exclusion in pancreatic cancer by restraining serotonin-dependent histone H3Q5 serotonylation
Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense desmoplasia and profound T-cell exclusion, yet the stromal metabolic programs that sustain this immune-refractory microenvironment remain poorly understood. Monoamine oxidase A (MAOA) is a mitochondrial enzyme that catalyzes serotonin...
ORGANISM(S): Mus musculus 
2026-07-29 | GSE341834 | GEO
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