Sort   by:  
 Page size 
TranscriptomicsExpression data from LNCap cell line treated with COP1 (RFWD2), ETV1, and JUN siRNAs
The proto-oncogenes ETV1, ETV4, and ETV5 encode members of the E26 transformation-specific (ETS) transcription factor family, which includes the most frequently rearranged and overexpressed genes in prostate cancer. Despite being critical regulators of development, little is known about their post-...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-27914 | biostudies-arrayexpress
MetabolomicsSubcutaneous white adipose tissue-derived extracellular vesicle maintains intestinal homeostasis via IgA biosynthesis in aging mice

To identify the potential iWAT-derived adipokines that regulate intestinal IgA biosynthesis, we conducted untargeted metabolomics in the serum of iFR and iSham mice. A total of 214 differential abundant metabolites were identified (log2FC >1 or <-1 and adjusted p-value <0.05) between the...

2025-09-05 | MTBLS12800 | MetaboLights
TranscriptomicsGENE EXPRESSION ALTERATIONS IN ADULT UTP14b (jsd) MICE BY CONDITIONAL KNOCKOUT OF ANDROGEN RECEPTOR IN SERTOLI CELLS
Spermatogenesis is dependent primarily on testosterone action on the Sertoli cells. Although the identification of testosterone-regulated target genes in Sertoli cells has been approached using microarray analysis to compare gene expression in mice with androgen receptor (AR) elimination in the Ser...
ORGANISM(S): Mus musculus 
2010-09-06 | E-GEOD-20918 | biostudies-arrayexpress
TranscriptomicsReciprocal communication between endometrial stromal cells and macrophages
Endometriosis is an inflammatory disease and bone marrow-derived cells are abundant in endometriotic lesions and in the peritoneal fluid of women with the disease. This study tested the hypothesis that reciprocal communication occurs between macrophages and cultured human endometrial stromal cells ...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-19834 | biostudies-arrayexpress
Transcriptomics40 IPF patients and 8 healthy controls
There is microscopic spatial and temporal heterogeneity of pathologic changes in idiopathic pulmonary fibrosis (IPF) lung tissue, which may relate to heterogeneity in pathophysiological mediators of disease and clinical progression. We measured gene expression in samples from lung biopsies or explan...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-53845 | biostudies-arrayexpress
TranscriptomicsSAGE Libraries from Highly Purified Mouse Hematopoietic Stem Cells from the E14.5 Fetal Liver and Adult Bone Marrow
Recent improvements in the development of methods for isolating functionally validated populations of nearly pure (>20%) murine hematopoietic stem cells (HSCs) have made it possible to analyze the molecular basis of the properties of these cells with increased precision. One intriguing feature of HS...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-13243 | biostudies-arrayexpress
TranscriptomicsAgilent 244A aCGH array for comparison of lung tumor CNA to high-throughput sequencing data
1 lung tumor was profiled for copy-number alterations with the high-resolution Agilent 244A aCGH Array. One lung tumor sample were assayed on the Agilent Human Genome CGH 244A Microarrays with the intent of comparing the genomic alterations reported by the array platform with those reported by high-...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-20574 | biostudies-arrayexpress
TranscriptomicsAssessment of mutation on expression levels
One lung tumor and its adjacent normal were profiled for expression levels with the Affymetrix HGU133 plus 2.0 array. One lung tumor sample and its adjacent normal were assayed on the Affymetrix HG-U133 plus 2.0 array to assess the effects of mutation on expression.
ORGANISM(S): Homo sapiens 
2011-02-21 | E-GEOD-20578 | biostudies-arrayexpress
GenomicsGenentech Colon Cancer Screen
Identifying and understanding changes in cancer genomes is essential for the development of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary human colon tumours by applying next-generation sequencing to characterize their exomes, transcriptomes and copy-number alte...
EGAS00001000288 | EGA
GenomicsThe mutation spectrum revealed by paired genome sequences from a lung cancer patient

Whole genome sequencing was applied to tumor and adjacent normal lung tissue in an individual non-small-cell lung cancer patient. We present an analysis of somatic changes identified throughout the tumor genome, including single-nucleotide variants, copy number variants, and large-scale chrom...

phs000299.v1.p1 | EGA
Sort   by:  
 Page size