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UnknownMatrix M(TM) adjuvanted virosomal H5N1 vaccine induces balanced Th1/Th2 CD4(+) T cell responses in man.
Not available
S-EPMC4896793 | biostudies-literature
ProteomicsEffects of PGRMC1 phosphorylation status on MIA PaCa-2 cells
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. Multiple different functions and cellular locations have been attributed to PGRMC1 in a variety of contexts, however the mechanisms underlying PGRMC1 biolo...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD014716 | Pride
Proteomics Swath Phosphorylation Pancreatic cancer 
UnknownHA-1-targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation.
Not available
S-EPMC11406181 | biostudies-literature
ProteomicsChemical genetic validation of CSNK2 substrates using an inhibitor-resistant mutant in combination with triple SILAC quantitative phosphoproteomics
Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase involved in the regulation of numerous key biological processes. Mapping the CSNK2-dependent phosphoproteome is necessary for better characterization of its fundamental role in cellular signalling. While ATP-c...
ORGANISM(S): Homo sapiens (Human) 
2022-07-14 | PXD033523 | Pride
Protein kinase ck2 U2os cells Csnk2 Silac Cx-4945 Phosphoproteomics Lc-ms/ms 
ProteomicsCompare total proteomics profile of PaCa-2 cells using 1D and 2D IDA LC and SWATH analysis
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. Multiple different functions and cellular locations have been attributed to PGRMC1 in a variety of contexts, however the mechanisms underlying PGRMC1 biolo...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD014789 | Pride
Cancer Proteomics Swath 
TranscriptomicsGene expression in Bach2-deficient and wildtype CD4 single-positive thymocytes from mixed chimeric animals
The role of FoxP3+ regulatory T (Treg) cells in the maintenance of immunological tolerance is well established. Recently, genome-wide association studies (GWAS) in humans have associated polymorphisms within the BACH2 locus encoding the transcription factor BTB and CNC homology 1, basic leucine zipp...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-42598 | biostudies-arrayexpress
GenomicsGenome-wide analysis of the role of FOG-1 in GATA-1 chromatin occupancy
We report ChIP-Seq data for GATA-1 and the FOG-binding mutant of GATA-1 (GATA-1^V205G) in G1ME cells, a Gata1-null cell line with both erythroid and megakaryocytic differentiation potential. We introduced HA-tagged GATA-1 or V205G into G1ME cells via retroviral transduction. The cells were crossli...
ORGANISM(S): Mus musculus 
2012-07-30 | E-GEOD-35644 | biostudies-arrayexpress
ProteomicsComparison of CX-4945 and SCG-CK2-1 as Inhibitors of CSNK2 using Quantitative Phosphoproteomics: Triple SILAC in combination with Inhibitor-Resistant CSNK2
Specificity is a limiting factor when using small-molecule inhibitors to study protein kinase signalling. Since inhibitor-resistant kinase mutants (i.e., drug-resistant alleles) remain active in the presence of inhibitor, they facilitate validation of on-target effects. By combining an inhibitor-res...
ORGANISM(S): Homo sapiens (Human) 
2023-08-14 | PXD038050 | Pride
Protein kinase ck2 Sgc-ck2-1 U2os cells Csnk2 Silac Cx-4945 Phosphoproteomics Lc-ms/ms 
TranscriptomicsDRM complex mutant lin-54 vs. H3K36 methyltransferase mutant mes-4 vs. lin-54; mes-4 double mutant vs. wild type C.elegans germline
Here we uncover antagonistic regulation of transcript levels in the germline of Caenorhabditis elegans hermaphrodites. The histone methyltransferase MES-4 marks genes expressed in the germline with methylated Lys36 on histone H3 (H3K36me) and promotes their transcription; MES-4 also represses genes ...
ORGANISM(S): Caenorhabditis elegans 
2013-11-05 | E-GEOD-52064 | biostudies-arrayexpress
TranscriptomicsStudies of target genes for signal transduction pathways (using a Ras1-, a Cdc42- and a Gap1-mutant) in the basidiomycete Schizophyllum commune.
Transcriptome changes associated with signal transduction mutants were analysed in order to identify targets of the distinct pathways of Ras1, Cdc42 and Gap1. Two monokaryons (12-43 and 4-39), a dikaryon (W22 x 12-43), a constitutive active Ras1 mutant (T2G12V, monokaryon), a Cdc42 mutant (G12V, mon...
ORGANISM(S): Schizophyllum commune 
2013-02-01 | E-GEOD-43965 | biostudies-arrayexpress
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