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ProteomicsLKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
KRAS-mutant lung cancers frequently have inactivating mutations in LKB1, which enhances tumor growth, metastasis, and immune evasion. This study shows that LKB1 suppresses JNK stress signaling, and its loss in KRAS-mutant cells leads to JNK hyperactivation and apoptotic rewiring, making them sensiti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-03-06 | MSV000097246 | MassIVE
ProteomicsTargeted degradation of the enhancer lysine acetyltransferases CBP and p300
The enhancer factors CBP/p300 maintain gene expression programs through lysine acetylation of chromatin and transcriptional regulators and by scaffolding functions mediated by several protein-protein interaction domains. We have designed dCBP-1, a compound that induces degradation of CBP/p300, and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-15 | MSV000086457 | MassIVE
ProteomicsThe impact of E2F/Dp inactivation on metabolism differs between muscles and fat body cells
We aim to determine the physiological impact of inactivating E2F in muscles and in adipose cells in vivo. To uncover the mechanism of action of E2F in each tissue we investigated the similarities between E2F-deficient tissues by comparing the proteomic profiles between muscles and fat cells. Our fin...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2021-02-11 | MSV000086854 | MassIVE
TranscriptomicsHER2 expression identifies dynamic functional states within circulating breast cancer cells
Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensit...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-75367 | biostudies-arrayexpress
TranscriptomicsOn the relationship of protein and mRNA dynamics in vertebrate embryonic development [RiboZero]
A biochemical explanation of development from the fertilized egg to the adult anatomy requires an understanding of the complement of proteins and RNAs expressed over time during embryogenesis. Here we present a comprehensive characterization of protein and mRNA dynamics across early development in X...
ORGANISM(S): Xenopus laevis 
2015-11-06 | E-GEOD-73904 | biostudies-arrayexpress
TranscriptomicsOn the relationship of protein and mRNA dynamics in vertebrate embryonic development [polyA]
A biochemical explanation of development from the fertilized egg to the adult anatomy requires an understanding of the complement of proteins and RNAs expressed over time during embryogenesis. Here we present a comprehensive characterization of protein and mRNA dynamics across early development in X...
ORGANISM(S): Xenopus laevis 
2015-11-06 | E-GEOD-73870 | biostudies-arrayexpress
ProteomicsTMT-ABPP profiling of SP3CHO in native 293T proteome
This TMT-ABPP experiment was performed in native 293T proteome treated with a range of concentrations of SP3CHO compounds.
ORGANISM(S): Homo sapiens (Human) 
2024-06-24 | PXD051803 | Pride
Abpp Tmt Chemoproteomic 
TranscriptomicsAKT Inhibition Promotes Non-autonomous Cancer Cell Survival [RNA-Seq]
Small-molecule inhibitors of AKT signaling are being in evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibito...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-71900 | biostudies-arrayexpress
TranscriptomicsAKT Inhibition Promotes Non-autonomous Cancer Cell Survival [GRO-Seq]
Small-molecule inhibitors of AKT signaling are being in evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibito...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-71898 | biostudies-arrayexpress
TranscriptomicsAKT Inhibition Promotes Non-autonomous Cancer Cell Survival [Cellular small RNA-Seq]
Small-molecule inhibitors of AKT signaling are being in evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibito...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-71893 | biostudies-arrayexpress
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