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ProteomicsA divergent cyclin/cyclin-dependent kinase complex controls progression through the atypical replicative cycles during Plasmodium berghei gametogony
Cell-cycle transitions are generally triggered by variations in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have evolved unique cell-cycles with a repertoire of ancestral CDKs and cyclins whose functions and interdependency remain elusive. Here, we sho...
ORGANISM(S): Plasmodium berghei ANKA 
2020-02-25 | PXD017308 | Pride
Soc2 Co-ip Crk5 Plasmodium berghei 
ProteomicsA Protein Kinase G-interacting protein regulates critical calcium signals in malaria parasites (phosphoproteomic)
In malaria parasites, cGMP signalling is mediated by a single cGMP-dependent protein kinase (PKG). One of the major functions of PKG is to control calcium signals essential for the parasite to exit red blood cells or for the transmission of the gametocyte stages to the mosquito. However, how PKG con...
ORGANISM(S): Plasmodium berghei ANKA 
2021-01-25 | PXD020189 | Pride
Gametocytes Lc-msms Plasmodium Phosphoproteomic 
ProteomicsA unique and divergent cyclin/cyclin-dependent kinase complex controls DNA replication during atypical cell-cycles of Plasmodium berghei gametogonyA unique and divergent cyclin/cyclin-dependent kinase complex controls DNA replication during atypical cell-cycles of Plasmodium berghei gametogony
Cell-cycle transitions are generally triggered by variations in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria parasites express ancestral CDKs and cyclins, whose functions and interdependency remain elusive. Here, we show that the unique Plasmodium berghei CDK-related kin...
ORGANISM(S): Plasmodium berghei ANKA 
2020-02-18 | PXD017283 | Pride
Lc-msms Plasmodium berhei Tmt10 Phosphorylation Cyclin-dependent kinase 
ProteomicsCRISPR screen decodes SWI/SNF chromatin remodeling complex assembly
The SWI/SNF (or BAF) complex is an essential chromatin remodeler that regulates DNA accessibility at developmental genes and enhancers. SWI/SNF subunits are among the most frequently mutated genes in cancer and neurodevelopmental disorders. These mutations are often heterozygous loss-of-function all...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-28 | PXD061408 | Pride
Mouse Lfq Orbitrap fusion lumos 
ProteomicsCRISPR screen decodes SWI/SNF chromatin remodeling complex assembly
The SWI/SNF (or BAF) complex is an essential chromatin remodeler that regulates DNA accessibility at developmental genes and enhancers. SWI/SNF subunits are among the most frequently mutated genes in cancer and neurodevelopmental disorders. These mutations are often heterozygous loss-of-function all...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-28 | PXD054392 | Pride
Orbitrap fusion lumos Baf complex Label-free 
ProteomicsA Protein Kinase G -interacting protein regulates critical calcium signals in malaria parasites (Co-IP)
In malaria parasites, cGMP signalling is mediated by a single cGMP-dependent protein kinase (PKG) . One of the major functions of PKG is to control calcium signals essential for the parasite to exit red blood cells or for the transmission of the gametocyte stages to the mosquito . However, how PKG c...
ORGANISM(S): Plasmodium berghei ANKA 
2021-01-25 | PXD020210 | Pride
Gametocytes Lc-msms Plasmodium Co-ip 
ProteomicsThe Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and zoites in Plasmodium berghei
Malaria-causing parasites of the Plasmodium genus undergo multiple developmental phases in the human and the mosquito hosts regulated by various post-translational modifications. While ubiquitination by multi-component E3 ligases is key to regulate a wide range of cellular processes in eukaryotes, l...
ORGANISM(S): Plasmodium berghei ANKA 
2023-02-17 | PXD035557 | Pride
Lc-msms Plasmodium berghei Malarai Dia Ubiquitome 
ProteomicsThe Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and zoites in Plasmodium berghei
Malaria-causing parasites of the Plasmodium genus undergo multiple developmental phases in the human and the mosquito hosts regulated by various post-translational modifications. While ubiquitination by multi-component E3 ligases is key to regulate a wide range of cellular processes in eukaryotes, l...
ORGANISM(S): Plasmodium berghei ANKA 
2023-02-17 | PXD035526 | Pride
Lc-msms Plasmodium berghei Malaria Immunoprecipitation 
ProteomicsUGO is a multipass membrane protein that is key to sense and transduce cues for schizont egress and gametocyte activation in malaria parasites
Many critical events in the Plasmodium lifecycle depend on tight regulation of cGMP homeostasis by guanylyl cyclases (GC) and phosphodiesterases including egress of schizonts from the host erythrocyte and activation of gametocytes upon a mosquito blood-feed. Both processes are triggered by distinct ...
ORGANISM(S): Plasmodium berghei ANKA 
2023-04-28 | PXD035569 | Pride
Lc-msms Gametocyte Immunoprecipitation Plasmodium berghei 
ProteomicsThe Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and zoites in Plasmodium berghei
Malaria-causing parasites of the Plasmodium genus undergo multiple developmental phases in the human and the mosquito hosts regulated by various post-translational modifications. While ubiquitination by multi-component E3 ligases is key to regulate a wide range of cellular processes in eukaryotes, l...
ORGANISM(S): Plasmodium berghei ANKA 
2023-02-21 | PXD040231 | Pride
Cullin1 Fbxo-1 Gamtocytes Plasmodium berghei Skp1 
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