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GenomicsNfatc1 Orchestrates Aging in Hair Follicle Stem Cells
Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used ChIP-seq to unfold genome-wide chromatin landscapes of Nfatc1 and dissect the biological relevence of its upstream BMP signaling in HFSC aging. Telogen quies...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52328 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hair follicle stem cell
Mouse keratinocytes were isolated from K15-EGFP transgenic mice for FACS sorting. RNA samples from EGFP-high and alpha-6 integrin positive cells (hair follicle stem cells) and from EGFP negative and alpha-6 integrin positive cells were used for Microarray analysis.
ORGANISM(S): Mus musculus 
2007-10-06 | E-GEOD-1096 | biostudies-arrayexpress
ProteomicsMouse wild-type and Anxa5-null utricles and hair bundles
The phospholipid- and Ca2+-binding protein annexin A5 (ANXA5) is the most abundant membrane-associated protein of ~P23 mouse vestibular hair bundles, present at ~15,000 copies per stereocilium, which is ~2% of the total protein there. Although seven other annexin genes are expressed in mouse utricle...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-09 | PXD003005 | Pride
Hair cells Annexins Vestibular Stereocilia 
TranscriptomicsLgr6 Marks Stem Cells in the Hair Follicle that Generate all Cell Lineages of the Skin
Mammalian epidermis consists of three self-renewing compartments: the hair follicle, sebaceous gland and interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative to the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair fol...
ORGANISM(S): Mus musculus 
2010-03-25 | E-GEOD-20269 | biostudies-arrayexpress
ProteomicsReprocessed: Chick utricle hair bundles and utricular epithelium—Orbitrap
This is a reanalysis of PXD000104. Purified hair bundles and utricular epithelium from E19-E20 chick inner ears were analyzed by LC-MS/MS to determine the abundant and enriched proteins of the hair bundle. This dataset used a Thermo Orbitrap Elite mass spectrometer for protein detection.
ORGANISM(S): Gallus gallus (Chicken) 
2015-11-17 | PXD002445 | Pride
Vestibular Hair cells Stereocilia Utricle 
TranscriptomicsExpression profiling of Bmal mutant dorsal skin at telogen of hair follicle cycling
Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadia...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-14006 | biostudies-arrayexpress
MetabolomicsOVCAR-3 spheroid-derived cells display distinct metabolic profiles
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid derived cells displayed numerous hallmarks of cancer stem cells, which are chemo and radioresistant cells thought to be a significant cau...
2015-01-08 | MTBLS152 | MetaboLights
TranscriptomicsDynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line
Hearing loss is most commonly caused by the destruction of mechanosensory hair cells in the ear. This condition is usually permanent: Despite the presence of putative hair-cell progenitors in the cochlea, hair cells are not naturally replenished in adult mammals. Unlike those of the mammalian ear, t...
ORGANISM(S): Danio rerio 
2014-04-01 | E-GEOD-55853 | biostudies-arrayexpress
TranscriptomicsExpression profiling of mouse dorsal skin during hair follicle cycling
Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadia...
ORGANISM(S): Mus musculus 
2009-07-17 | E-GEOD-11186 | biostudies-arrayexpress
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
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